Neoplasms

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Germinoma

Neoplasms, Germ Cell and Embryonal

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Central Nervous System Germinoma

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1. Four cycles of chemotherapy with carboplatin, etoposide, (+ bleomycin) and cyclophosphamide, etoposide, (+ bleomycin) regimen
2. Reduced dose of radiotherapy

   * Without seeding: 18 Gy to ventricle + 12.6 Gy to primary site
   * With seeding: craniospinal irradiation 18 Gy + 12.6 Gy to primary site

Reduced dose of radiotherapy

Ki Woong Sung, MD, PhD

Ki Woong Sung

The purpose of this study is to evaluate the outcome of intracranial germinoma treated with chemotherapy plus reduced radiotherapy.

Treatment outcome of intracranial germinoma is excellent with radiotherapy/chemotherapy. However, late sequelae are unavoidable especially with craniospinal irradiation, and various efforts have been done to reduce the dose and extent of radiotherapy. In this study, chemotherapy and further reduced dose of radiotherapy will be used to minimize the late sequelae in the patients with intracranial germinoma.

Chemotherapy Plus Reduced Radiotherapy in Intracranial Germinoma

Treatment of Intracranial Germinoma With Chemotherapy Prior to Reduced Dose and Volume of Radiotherapy

Samsung Medical Center

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Chemotherapy Plus Reduced Radiotherapy in Intracranial Germinoma	NCT02782754	Intracranial Ge...	Carboplatin Etoposide Cyclophosphamid... Bleomycin Reduced dose of...	3 Years - 30 Years	Samsung Medical Center
Chemotherapy Plus Reduced Radiotherapy in Intracranial Germinoma	NCT02782754	Intracranial Ge...	Carboplatin Etoposide Cyclophosphamid... Bleomycin Reduced dose of...	3 Years - 30 Years	Samsung Medical Center

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