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Reduced intensity conditioning with allogeneic transplant

John E. Levine, MS MD

The purpose of this study is to determine whether a less-intensive preparative therapy followed by an allogeneic peripheral stem cell transplantation will provide an effective treatment for your disease and whether it will be associated with fewer side effects.

Combinations of high-dose chemotherapy and radiation therapy (preparative regimen) followed with allogeneic bone marrow or stem cell transplantation from an unrelated donor is a current treatment approach. Chemotherapeutic drugs and radiation are given in higher doses to increase their effectiveness. High-dose chemotherapy and radiation therapy generally affect cells that are dividing. They are used to treat cancer because cancer cells divide more often than most other cells. High-dose treatment severely damages the patient's bone marrow so that the patient no longer is able to produce needed blood cells. Peripheral stem cell transplantation allows stem cells that were damaged by treatment to be replaced with healthy stem cells that can produce the blood cells the patient needs. Patients experience a number of complications after transplantation. Some are temporary and relatively minor; yet others can be life threatening. Many doctors consider high-dose chemotherapy, by itself or with radiation, and bone marrow or stem cell transplantation as the best available treatment option for diseases under specific circumstances. However, this study will explore whether a less-intensive preparative therapy before the peripheral stem cell transplantation will prove to be safer, have less side effects, and be an effective treatment for certain diseases.

Low-Intensity Preparation and Allogeneic Transplant in Patients With Cancers of the Blood

Low-Intensity Preparative Regimen and Allogeneic Peripheral Blood Stem Cell Transplantation From Unrelated Donor in Patients With Hematologic Malignancy

University of Michigan Rogel Cancer Center

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Low-Intensity Preparation and Allogeneic Transplant in Patients With Cancers of the Blood	NCT00146055	Myeloma, Plasma... Lymphoma, Malig... Myeloproliferat... Myelodysplastic... Waldenstrom's M...	Reduced intensi...	-	University of Michigan Rogel Cancer Center
Low-Intensity Preparation and Allogeneic Transplant in Patients With Cancers of the Blood	NCT00146055	Myeloma, Plasma... Lymphoma, Malig... Myeloproliferat... Myelodysplastic... Waldenstrom's M...	Reduced intensi...	-	University of Michigan Rogel Cancer Center
Low-Intensity Preparation and Allogeneic Transplant in Patients With Cancers of the Blood	NCT00146055	Myeloma, Plasma... Lymphoma, Malig... Myeloproliferat... Myelodysplastic... Waldenstrom's M...	Reduced intensi...	-	University of Michigan Rogel Cancer Center
Low-Intensity Preparation and Allogeneic Transplant in Patients With Cancers of the Blood	NCT00146055	Myeloma, Plasma... Lymphoma, Malig... Myeloproliferat... Myelodysplastic... Waldenstrom's M...	Reduced intensi...	-	University of Michigan Rogel Cancer Center

Spots Global Cancer Trial Database for reduced intensity conditioning with allogeneic transplant