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Squamous Cell Carcinoma of Head and Neck

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Neoplasms, Squamous Cell

Head and Neck Neoplasms

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Immunomodulating Agents

In resectable HPV-negative locally advanced head and neck squamous cell carcinoma, 3 cycles of preoperative neoadjuvant chemotherapy combined with immunotherapy are proposed, in patients with significant tumor shrinkage (≥50%) as assessed by imaging, to conduct research on narrowing the scope of surgery, preserve the patient's organ function, improve or improve the quality of life, and achieve a curative effect that is not inferior to traditional radical surgery

Reducing Excision Margins After Neoadjuvant Chemoimmunotherapy

Reducing Excision Margins

kunyu Mr Yang, Doctor

This study aims to explore the 2-year DFS (disease-free survival) rate and organ retention rate and to explore the ORR, PCR rate, 2y-OS， and quality of life of patients.

This study aims to explore the 2-year DFS (disease-free survival) rate and organ retention rate after AP chemotherapy combined with anti-PD-1 antibody neoadjuvant treatment for HPV negative operable locally advanced head and HNSCC, and to explore the ORR, PCR rate, 2y-OS, and quality of life of patients.

Reducing Excision Margins After Neoadjuvant Chemoimmunotherapy for HPV Negative Resectable Locally Advanced HNSCC

Reducing Excision Margins After Neoadjuvant Chemoimmunotherapy for HPV Negative Resectable Locally Advanced Head and Neck Squamous Cell Carcinoma (REMATCH)

Wuhan Union Hospital, China

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Reducing Excision Margins After Neoadjuvant Chemoimmunotherapy for HPV Negative Resectable Locally Advanced HNSCC	NCT05459415	Squamous Cell C... Neoadjuvant The... Resection Margi...	Reducing Excisi...	18 Years - 70 Years	Wuhan Union Hospital, China
Reducing Excision Margins After Neoadjuvant Chemoimmunotherapy for HPV Negative Resectable Locally Advanced HNSCC	NCT05459415	Squamous Cell C... Neoadjuvant The... Resection Margi...	Reducing Excisi...	18 Years - 70 Years	Wuhan Union Hospital, China

Spots Global Cancer Trial Database for reducing excision margins