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Propofol

High-flow nasal oxygenation combined with nasopharyngeal airway was used in obese patients who are scheduled to undergo gastrointestinal endoscopy procedures sedated with propofol.

Regular nasal cannula combined with nasopharyngeal airway was used in obese patients who are scheduled to undergo gastrointestinal endoscopy procedures sedated with propofol.

The patients receive an oxygen flow of 30 L/min for preoxygenation with a high-flow oxygenation device before losing of conscious. At the time of the abolition of the eyelash reflex, the gas flow was increased to 60 L/min with an inspired oxygen fraction 100% and the nasopharyngeal airway was placed.

High-flow nasal oxygenation combined with nasopharyngeal airway

The patients receive an oxygen flow of 6 L/min for preoxygenation with a regular nasal cannula until the end of procedure. At the time of abolition of the eyelash reflex, the nasopharyngeal airway was placed.

Regular nasal cannula combined with nasopharyngeal airway

Diansan Su

Lingke Chen

Jiang Zhu

Obesity is associated with adverse airway events including desaturation during deep sedation. Previous studies have suggested that high-flow nasal oxygenation may be superior to regular (low-flow) nasal cannula for prevention of hypoxia during Sedated Gastrointestinal Endoscopy in non-obesity patients. The prerequisite of high-flow nasal oxygenation is keeping airway patency. Our pervious study demonstrated that nasopharyngeal airway has the similar efficacy of jaw-lift. In present study we aimed to determine whether high-flow nasal oxygenation combined with nasopharyngeal airway could reduce the incidence of hypoxia during Sedated Gastrointestinal Endoscopy in obese patients.

HFNO Combined With NPA Reduces Hypoxia During Sedated Gastrointestinal Endoscopy In Obese Patients

High-Flow Nasal Oxygenation Combined With Nasopharyngeal Airway Reduces The Incidence Of Hypoxia During Gastrointestinal Endoscopy Sedated With Propofol In Obese Patients: A Prospective, Randomized Clinical Trial

Severe hypoxia refers to SpO2\<75% lasting for any time, or 75%≤SpO2\<90%, ≥60s

Subclinical respiratory depression refers to 90%≤ SpO2\<95%

Other adverse events recorded by tools proposed by the World Society of Intravenous Anesthesia International Sedation Task Force

Second Affiliated Hospital of Soochow University

Dushu Lake Hospital Affiliated to Soochow University

RenJi Hospital

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
HFNO Combined With NPA Reduces Hypoxia During Sedated Gastrointestinal Endoscopy In Obese Patients	NCT05526339	Gastric Cancer Gastric Ulcer Intestinal Canc... Intestinal Poly...	High-flow nasal... Regular nasal c...	19 Years - 80 Years	RenJi Hospital
HFNO Combined With NPA Reduces Hypoxia During Sedated Gastrointestinal Endoscopy In Obese Patients	NCT05526339	Gastric Cancer Gastric Ulcer Intestinal Canc... Intestinal Poly...	High-flow nasal... Regular nasal c...	19 Years - 80 Years	RenJi Hospital
HFNO Combined With NPA Reduces Hypoxia During Sedated Gastrointestinal Endoscopy In Obese Patients	NCT05526339	Gastric Cancer Gastric Ulcer Intestinal Canc... Intestinal Poly...	High-flow nasal... Regular nasal c...	19 Years - 80 Years	RenJi Hospital

Spots Global Cancer Trial Database for regular nasal cannula combined with nasopharyngeal airway