Neoplasms

All Conditions

Rare Diseases

Chordoma

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Patients undergo resection surgery in our hospital.

Resection surgery

Zan Chen, MD. PHD.

Chordoma is a rare but locally invasive cancer that arises from the embryonic notochord. Total resection is challenging in mobile spine because of the complex anatomy and bone invasion.

A Prospective Study of Surgical Treatment Strategies for Chordoma

Clinical and radiographic assessments of excision extension of tumor.

Overall Survival of patient underwent surgery.

Progression-Free Survival of patient underwent surgery.

Disease Free Survival of patient underwent surgery.

Objective Response Rate of patient underwent surgery.

Xuanwu Hospital, Beijing

Digestive System Diseases

Gland and Hormone Related Diseases

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Pancreatic Neoplasms

Ovarian Neoplasms

Carcinoma, Ovarian Epithelial

Liver Neoplasms

Duodenal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Endocrine Gland Neoplasms

Ovarian Diseases

Adnexal Diseases

Genital Diseases, Female

Genital Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Genital Neoplasms, Female

Urogenital Neoplasms

Endocrine System Diseases

Gonadal Disorders

Gastrointestinal Diseases

Pancreatic Cancer

Ovarian Cancer

Ovarian Epithelial Cancer

Hematinics

All Drugs and Chemicals

Gastrointestinal Agents

Liver Extracts

Pancrelipase

Pancreatin

confocal laser endomicroscopy : 10 to 15 minutes endomicroscopy procedure to obtain real time microscopical images of healthy and malignant tissue of the targeted organs

probe-based and needle-based confocal laser endomicroscopy

confocal laser endomicroscopy

Brice GAYET, MD

This study aims at demonstrating the feasibility of probe-based confocal laser endomicroscopy (pCLE) and needle-based confocal laser endomicroscopy (nCLE).

Contraindications for resection surgery may sometimes be missed during exploratory surgical procedures. That may lead to an incomplete thus useless surgery and delay the right treatment.

The objectives of this study are to improve the detection of cancer extension during exploratory procedures and to guide resection to ensure clear margins.

This study involves several innovations including :

* the robotization of the confocal miniprobe for a better an d more precise handling of the probe
* the use of different contrast agent and administration mode (Fluorescein, Patented Blue V, Indocyanine Green via intravenous, interstitial or topical administration)
* the communication between the operative room and the pathologist room for a real time assessment by the surgeon and by the pathologist of the endomicroscopic images

Feasibility Study for Robotic Endomicroscopy to Better Define Resection Strategies (PERSEE)

Essai de faisabilité Pour Une Endomicroscopie Robotisée Dans la redéfinition Des Stratégies d&Apos;ExérèsE

during or after each procedure, the surgeon and the pathologists are asked to assess the quality of audiovisual communication

each sequence acquired during the cases will be annotated as to which organ it is, and the final diagnosis of the specimen (healthy, cancerous, inflammation, etc ...). Thanks to this, a more complete atlas of images obtained in digestive organs and conditions will be developed. This atlas will be used to describe image interpretation criteria for endomicroscopic images of various organs and conditions. This work will be done in conjunction by the investigators, the histopathologist, and an Mauna Kea Technologies representative familiar with image interpretation in current endomicroscopy indications.

during or after each procedure, the surgeon is asked to assess the ease of manipulation of the device

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
A Prospective Study of Surgical Treatment Strategies for Chordoma	NCT05707767	Chordoma of Spi... Surgery	Resection surge...	18 Years - 70 Years	Xuanwu Hospital, Beijing
A Prospective Study of Surgical Treatment Strategies for Chordoma	NCT05707767	Chordoma of Spi... Surgery	Resection surge...	18 Years - 70 Years	Xuanwu Hospital, Beijing
Feasibility Study for Robotic Endomicroscopy to Better Define Resection Strategies (PERSEE)	NCT02312167	Cancer of Diges... Ovarian Cancer	confocal laser ...	18 Years -	Institut Mutualiste Montsouris
A Prospective Study of Surgical Treatment Strategies for Chordoma	NCT05707767	Chordoma of Spi... Surgery	Resection surge...	18 Years - 70 Years	Xuanwu Hospital, Beijing
Feasibility Study for Robotic Endomicroscopy to Better Define Resection Strategies (PERSEE)	NCT02312167	Cancer of Diges... Ovarian Cancer	confocal laser ...	18 Years -	Institut Mutualiste Montsouris
Feasibility Study for Robotic Endomicroscopy to Better Define Resection Strategies (PERSEE)	NCT02312167	Cancer of Diges... Ovarian Cancer	confocal laser ...	18 Years -	Institut Mutualiste Montsouris

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