Infections

All Conditions

Ear, Nose, and Throat Diseases

Nervous System Diseases

Symptoms and General Pathology

Respiratory Tract (Lung and Bronchial) Diseases

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Rare Diseases

Hearing Loss

Deafness

Communicable Diseases

Post-Acute COVID-19 Syndrome

Papillomavirus Infections

Rhinosinusitis

Otorhinolaryngologic Diseases

Sinusitis

Syndrome

COVID-19

Rhinitis

Respiratory Tract Infections

Paranasal Sinus Diseases

Nose Diseases

Respiratory Tract Diseases

Pneumonia

Pneumonia, Viral

Virus Diseases

Coronavirus Infections

Coronaviridae Infections

Nidovirales Infections

RNA Virus Infections

Lung Diseases

Post-Infectious Disorders

Chronic Disease

Disease Attributes

Sexually Transmitted Diseases

Sexually Transmitted Diseases, Viral

DNA Virus Infections

Tumor Virus Infections

Genital Diseases

Urogenital Diseases

Chronic Graft Versus Host Disease

Acute Graft Versus Host Disease

Emanuel Maitz, MD

Reinhard Domanyi, MD

The aim of the present study will be to evaluate in conscripts at the military induction board the prevalence of rhinosinusitis, the prevalence of HPV vaccinations, the prevalence of hearing impairments and the prevalence of long-COVID symptoms and further, to evaluate different factors that influence on the one hand the prevalence (urban-bred, non-urban-bred) and on the other hand symptoms (ENT-surgeries in medical history). Further, we want to evaluate if there is a correlation between subjective symptoms and apparated-based diagnostic investigations.

Therefore, questionnaires and data of medical examinations, aquired routinely at the military induction board, will be analysed.

Rhinosinusitis is a very common complaint at ENT departments, whereby symptoms of the underlying disease are varying. Therefore, there is growing interest in prevalence of rhinosinusitis including differences in prevalence's depending on where the patient grew up. Further, there is growing interest in answering the question if different factors, including ENT-surgeries in medical history have an impact on symptoms of rhinosinusitis.

Within the past few years there is growing interest in carring out as many HPV-vaccinations as possible in order to reduce the prevalence of HPV-associated cancers.

Further, in adolescents there is a growing number of hearing impairments, including hearing loss and/or sounds in the ears.

Next, since the beginning of the COVID pandemic there are very common complaints in adult and pediatric patients about persistent medical problems for weeks or months after an acute SARS-CoV-2-infection and cannot be explained by another diagnosis, called long- Covid disease.

The military induction board of conscripts enables access to data from a cross-section of the population, with common characteristics of gender and age.

In the present study we want therefore to evaluate in conscripts at the military induction board the prevalence of rhinosinusitis, the prevalence of HPV vaccinations, the prevalence of hearing impairments and the prevalence of long-COVID symptoms and further, to evaluate different factors that influence on the one hand the prevalence (urban-bred, non-urban-bred) and on the other hand symptoms (ENT-surgeries in medical history). Further, we want to evaluate if there is a correlation between subjective symptoms and apparated-based diagnostic investigations.

only Austrian males (conscripts), who are invited at the military induction board

Prevalence of ENT Diseseas

Prevalence Study of ENT-related Diseases in Conscripts at the Military Induction Board

To assess whether there is a difference in prevalence of rhinosinusitis in urban-bred conscripts compared to non-urban-bred conscripts.

To assess whether there is a difference in prevalence of human papilloma virus vaccinations in urban-bred conscripts compared to non-urban-bred conscripts.

To assess whether there is a difference in prevalence of hearing impairment in urban-bred conscripts compared to non-urban-bred conscripts.

To assess whether there is a difference in prevalence of long-COVID disease in vaccinated conscripts compared to no-vaccinated conscripts.

To assess prevalence of rhinosinusitis in conscripts at the military induction board

To assess the different symptoms of rhinosinusitis in conscripts at the military induction board

To assess the prevalence of rhinosinusitis in conscripts with previous ENT-surgeries

To assess differences in symptoms in rhinosinusitis in conscripts with previous ENT-surgeries

To assess the combined prevalence of rhinosinusitis and chronic pulmonary diseases in conscripts

To assess the difference in prevalence of subjective symptoms of rhinosinusitis compared to objective (apparatus based and laboratory based) symptoms of rhinosinusitis

To analyse demographic data in conscripts with rhinosinusitis

To assess the prevalence of HPV vaccines among conscripts at the military induction board

To assess knowledge about HPV and HPV vaccinations and in dependent of that prevalence of HPV vaccines among conscripts at the military induction board

To assess the prevalence of hearing impairment in conscripts at the military induction board

To assess the difference in prevalence of subjective symptoms of hearing impairment compared to objective (apparatus based and laboratory based) signs of hearing impairment

To analyse demographic data in conscripts with hearing impairment

To assess the prevalence of long-COVID in conscripts at the military induction board

To assess different symptoms of long-COVID in conscripts at the military induction board

To assess the prevalence of previous COVID 19 infections in conscripts at the military induction board

To analyse demographic data in conscripts with long-COVID

Medical University of Graz

Neoplasms

Digestive System Diseases

Mouth and Tooth Diseases

Nasal Polyps

Colorectal Neoplasms

Nasopharyngeal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Pharyngeal Neoplasms

Otorhinolaryngologic Neoplasms

Head and Neck Neoplasms

Nasopharyngeal Diseases

Pharyngeal Diseases

Stomatognathic Diseases

Pharmaceutical Solutions

All Drugs and Chemicals

Anti-Inflammatory Agents

Respiratory System Agents

Budesonide

Bronchodilator Agents

Anti-Asthmatic Agents

Glucocorticoids

Hormones

Hormone Antagonists

Buparid 1 mg budesonide/2 ml nebuliser solution

Budes® Nasal Spray 50 µg budesonide/pump

Sven Becker, MD

The study should create data for the selection of a clinically relevant primary endpoint to assess the efficacy and safety of Buparid/PARI SINUS as compared to Budes Nasal Spray in the therapy of chronic rhinosinusitis (CRS) with polyposis nasi in adult patients. Ideally, the selected parameter should allow a correlation between an objective methodology and the clinical outcome of the study patients.

Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis With Polyposis Nasi

A Pilot Study to Investigate the Efficacy and Safety of Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis (CRS) With Polyposis Nasi in Adult Patients

Health-specific quality of life was assessed by means of the self-rated, 22-item Sino-Nasal Outcome Test (SNOT-22). The SNOT-22 total score has a (theoretical) range of 0 - 110 points, with higher scores indicating more severe impairment.

Presented are the mean values of the SNOT-22 total score after 24 weeks minus value at day 0 (baseline).

Nasal obstruction was assessed using the method of rhinomanometry by measuring the positive nasal inspiratory flow (PNIF). For the assessment the subject had to inhale maximally through the nose three times and the highest value of flow rate was recorded after 4 weeks and 8 weeks of treatment.

Inflammation of the nasal mucosa and paranasal sinus was assessed using the Lund-Mackay score based on magnetic resonance imaging. The score can take on values between 0 and 24 points, with higher values indicating more severe impairment. The outcome investigated is the intraindividual mean score of 2 independent raters assessing the same images.

Treatment-emergent adverse events (AEs) Each participant has been monitored for adverse events up to 26 weeks. All patients withdrawn from the study will be followed-up for AEs or SAEs for further 2 weeks or 4 weeks, respectively.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Prevalence of ENT Diseseas	NCT06105346	Conscripts Military Induct... ENT Disease Rhinosinusitis ... Rhinosinusitis HPV Infection HPV Vaccine Long COVID ENT Surgery		17 Years - 19 Years	Medical University of Graz
Buparid/PARI SINUS Versus Budes® Nasal Spray in the Therapy of Chronic Rhinosinusitis With Polyposis Nasi	NCT01946711	Rhinosinusitis Chronic Polypos...	Budesonide Budesonide	18 Years -	Pari Pharma GmbH

Spots Global Cancer Trial Database for rhinosinusitis