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the group underwent laparoscopic right hemicolectomy with CME. In complete mesocolic excision group (CME), the dissecting extent includes the lymphatic and fat tissues surrounding the root of ascending mesocolon, which situated on the surface of superior mesenteric vein, and the root of right half of transverse mesocolon, which situated on the surface of pancreas neck.

the group underwent laparoscopic right hemicolectomy with D3 lymph node dissection. In D3 lymph node dissection group(D3), the lymph node dissection is based on ligating the supplying vessels close to the right-side of superior mesenteric vein and clean up the surrounding lymph node and adipose tissue. No.6 lymph node should be dissected in this group.

the group underwent laparoscopic right hemicolectomy with CME. In CME group, in addition to D2 dissection, the whole mesocolon, from ascending colon to right half transverse colon, as well as the central lymph nodes should be entirely removed.

Intervention: Procedure: Complete mesocolic excision (CME)

the group underwent laparoscopic right hemicolectomy with D3 lymph node dissection. In D3 group, the mesocolon should be removed and the dissection involves the paracolon and intermediate lymph nodes,including No.6 lymph node, which along the feeding vessels.

Intervention: Procedure: D3 radical operation

Minhua Zheng, PhD

Hiju Hong, PhD Student

To standardize the surgery for advanced right hemi colon cancer with laparoscopy and investigate whether extended lymphadenectomy (CME) could improve disease-free survival in patients with right colon cancer, compared with D3 radical operation in laparoscopic colectomy.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Standardization of Laparoscopic Surgery for Right Hemi Colon Cancer (SLRC)	NCT02942238	Overall Surviva... Postoperative C... Metastasis Stage, Colon Ca...	CME D3	18 Years - 75 Years	Ruijin Hospital
Standardization of Laparoscopic Surgery for Right Hemi Colon Cancer (SLRC)	NCT02942238	Overall Surviva... Postoperative C... Metastasis Stage, Colon Ca...	CME D3	18 Years - 75 Years	Ruijin Hospital

Spots Global Cancer Trial Database for right hemi colon cancer