Symptoms and General Pathology

All Conditions

Nervous System Diseases

Behaviors and Mental Disorders

Wounds and Injuries

Frailty

Delirium

Cognitive Dysfunction

Brain Injuries

Postoperative Cognitive Complications

Emergence Delirium

Confusion

Neurobehavioral Manifestations

Neurologic Manifestations

Neurocognitive Disorders

Mental Disorders

Psychotic Disorders

Cognition Disorders

Postoperative Complications

Central Nervous System Depressants

All Drugs and Chemicals

Anesthetics

Elective urologic oncology surgeries such as radical nephrectomy, radical cystectomy, radical prostatectomy in older than 65 years

Patients are monitored by near infrared spectroscopy before anesthesia induction until end of the operation. Graphical presentation of cerebral oxygenation during surgery evaluated by INVOS Analytics Tool Version 1.2.

Near Infrared Spectroscopy (NIRS)

Blood samples are obtained before and after surgery. S-100, Neuron specific enolase (NSE), Interleukin-6 (IL-6), High Mobility Group Box Protein (HMGB-1) are going to be studied by ELISA method after data collection process end.

Blood sample

ACE-III is administered to study participants one day before surgery, 1 week after surgery, and three months after surgery to diagnose postoperative cognitive dysfunction.

Addenbrooke Cognitive Examination III (ACE-III)

Confusion Assessment Method is administered to study participants in postoperative recovery room to diagnose postoperative delirium.

Confusion Assessment Method

Emre Şentürk, MD

Meltem Savran Karadeniz, Assoc.Prof.

Meltem Savran Karadeniz, Assoc. Prof.

Postoperative cognitive changes are more common in elderly patients, which can result in poor quality of life, loss of workforce, disability, early retirement, physical-social dependence, increased health care cost and premature mortality. Postoperative cognitive complications are also quite common in extensive oncological surgeries. In this study, our aim is to evaluate the relationship between the development of postoperative cognitive dysfunction (POCD) in geriatric urologic oncology patients with brain injury and inflammatory markers \[S100 β, neuron specific enolase (NSE), interleukin 6 (IL-6) and high mobility group box-1 (HMGB-1 protein)\].

The incidence of POCD changes by age group, type of surgery, testing neuropsychological tests, timing of tests, and the method used for diagnosis. In non-cardiac surgery over the age of 60; the incidence of POCD was 26% in the postoperative 1st week and 10% in the postoperative 3rd month. Although old age is an important risk factor, POCD incidence of up to 36.6% has been reported in a younger period. Major cancer surgery is an important risk factor for development of POCD.

Numerous biomarkers such as; S100β, NSE, Human IL-6, HMGB-1 protein; have been evaluated in studies to determine the diagnosis, prognosis, stage and treatment of POCD.

In this study, our aim is to evaluate the relationship between the development of postoperative cognitive dysfunction (POCD) in geriatric urologic oncology patients with brain injury and inflammatory markers. (S100β, NSE, Human IL-6 and HMGB-1 protein).The hypothesis of our study is that postoperative brain injury and inflammatory markers (S100β, NSE, Human IL-6 and HMGB-1 protein) will be higher in patients who develop POCD compared to patients who do not develop POCD in geriatric urologic oncology surgery.

Blood samples are collected from study participants after anesthesia induction and after the end of the operation.

Postoperative Cognitive Dysfunction in Elderly Urologic Oncology Patients (POCD)

Evaluation of the Relationship Between Postoperative Cognitive Dysfunction and Brain Injury Biomarkers In Geriatric Urologic Oncology Patients

Test score is between 0-100. 100 is the best point and 0 is the worst point in the test. The test has five cognitive domains including attention, memory, language, visuospatial function, and verbal fluency. Patients who score less than 88 in preoperative tests will be diagnosed with mild cognitive impairment.

POCD is diagnosed by 1 standard deviation decrease from the preoperative test scores.

Blood S 100β concentration is determined by an enzyme-linked immunosorbent assay kit.

HMGB1 concentration is determined by an enzyme-linked immunosorbent assay kit.

h-NSE concentration is determined by an enzyme-linked immunosorbent assay kit.

Blood IL-6 concentration is determined by an enzyme-linked immunosorbent assay kit.

Postoperative delirium is diagnosed by confusion assessment method.

Cerebral hypoxia is defined as reduction of regional oxygen saturation by 10 % from baseline before surgery.

Stroke, transient ischemic attack, arrhythmia, heart failure, myocardial injury, respiratory failure, pneumonia, ileus, acute kidney injury, prolonged length of stay, mortality.

Spots Global Cancer Trial Database for s 100β

Every month we try and update this database with for s 100β cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for s 100β

Every month we try and update this database with for s 100β cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for s 100β cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.