Neoplasms

All Conditions

Behaviors and Mental Disorders

Rare Diseases

Teratoma

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Quality of Life

Sacrococcygeal Teratoma

Mohamed K Khalil

Sacrococcygeal teratoma is one of the most common tumors that occur in the neonatal period. It presents either as a mass protruding from the sacrococcygeal region or as a pelviabdominal mass according to the type. Surgical excision is the main treatment, most masses are benign, however some are malignant and require radiotherapy or chemotherapy. Complications may occur due to pressure resulting from the tumor growth in the fetal period, or due to damage to important near tissues during surgical excision. Postoperative complications may be urinary as neurogenic bladder, Lower gastrointestinal as constipation, soiling or incontinence. In this work we study the outcomes of fecal continence through a questionnaire and its effect on the quality of life of the affected children.

Fecal Continence Outcomes and Quality of Life After Excision of Sacrococcygeal Teratoma (Retrospective Study)

Fecal Continence Outcomes and Quality of Life After Excision of Sacrococcygeal Teratma (Retrospective Study)

Sohag University

resident-pediatric surgery department

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Symptoms and General Pathology

Nervous System Diseases

Urinary Incontinence

Urinary Bladder, Neurogenic

Enuresis

Neurologic Manifestations

Urinary Bladder Diseases

Urologic Diseases

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Male Urogenital Diseases

Sarah GARNIER

Sacrococcygeal teratomas are the most common neonatal tumors and require rapid and complete resection. Tumor nerve compression and pelvic surgical sequelae may lead to many and varied voiding disorders. Data concerning long-term vesico-sphincteric disorders are conflicting. Some studies find good functional results \[Cozzi et al., 2008; Draper et al., 2009\]. However other authors reveal neurologic bladder with detrusor sphincter dyssynergia \[Hambraeus et al., 2018\] and rise concerned about long-term renal function \[Khanna et al., 2019; Rehfuss et al., 2020\] even in the absence of clinical voiding disorders. Most of studies include young patients with other malformations such as anorectal malformations or dysraphisms which may impact the results. The main objective is to assess bladder dysfunction in children aged 6 to 18 years after isolated sacrococcygeal teratoma resection.

Voiding Disorders in Children After Sacrococcygeal Teratoma Resection

Presence of voiding disorders will be assessed by the scale: Dysfonctional voiding scoring system

The Presence of defecation disorders will be assessed by the scale: Bristol stool scale

the Presence of secondary neurological bladder will be assessed by the uroflowmetry

University Hospital, Montpellier

Fetuses and infants diagnosed with sacrococcygeal teratoma and cared for between 2007 and 2017 in the main Parisian fetal medicine and pediatric surgery units: Necker-Enfants Malades Hospital, Antoine Béclère Hospital, Armand Trousseau Hospital, Robert Debré Hospital and Le Kremlin-Bicêtre Hospital.

Sabine Sarnacki, MD, PhD

Nicolas Vinit, Resident, MSc

Sacrococcygeal teratoma (SCT) is the most common fetal and neonatal tumor. However, predicting factors of evolution, sequelae and relapse are still unreliable because of small-cohort studies. This study aims at identifying prenatal and postnatal prognostic factors of evolution of SCT during pregnancy, of postnatal relapse, and of medium and long-term sequelae (urinary, digestive, esthetic, psychologic) in order to improve parental counseling when the diagnosis of SCT is made during pregnancy.

Sacrococcygeal teratoma (SCT) is the most common fetal and neonatal tumor. Although mostly benign, SCT can lead to perinatal mortality and long-term sequelae.

Three main risks occur throughout the evolution of SCT:

1. A perinatal life-threatening risk related to the importance of vascularization since SCT can lead to a true arteriovenous fistula with the risk of cardiac failure
2. A risk of benign or malignant tumor recurrence
3. A risk of medium and long-term sequelae, mostly urinary and/or digestive disorders but also aesthetic and psychologic.

In most cases, a prenatal diagnosis is made for which physicians are expected to give a prognosis and counsel parents about medium and long-term complications. However, there is no robust data to date correlating prenatal and postnatal features to prenatal and postnatal evolution of the tumor. The situation is all the more delicate as the information given by the physician can lead to the parent's will to terminate the pregnancy. This retrospective multicentric study aims at identifying prenatal and postnatal prognostic factors of SCT evolution during pregnancy, the occurrence of postnatal relapse after surgical excision, and medium- and long-term sequelae. The primary goal of this study is to improve prenatal parental counseling when the diagnosis of SCT is made.

Improving Prenatal Parental Counseling in Cases of Sacrococcygeal Teratoma

Improving Prenatal Parental Counseling in Cases of Sacrococcygeal Teratoma: a Multicenter Retrospective Study With Review of the Literature

Presence of digestive, urinary, cosmetic or psychologic postnatal sequelae

Intrauterine fetal death, termination of pregnancy or neonatal death

Relapse requiring subsequent surgical procedures and/or chemotherapy

Study title	NCT ID	Conditions	Eligibility	Organization
Fecal Continence Outcomes and Quality of Life After Excision of Sacrococcygeal Teratoma (Retrospective Study)	NCT06133036	Sacrococcygeal ...	3 Years - 18 Years	Sohag University
Voiding Disorders in Children After Sacrococcygeal Teratoma Resection	NCT05182853	Sacrococcygeal ... Neurogenic Blad... Voiding Disorde...	6 Years - 18 Years	University Hospital, Montpellier
Improving Prenatal Parental Counseling in Cases of Sacrococcygeal Teratoma	NCT04623658	Sacrococcygeal ...	- 10 Years	Assistance Publique - Hôpitaux de Paris
Fecal Continence Outcomes and Quality of Life After Excision of Sacrococcygeal Teratoma (Retrospective Study)	NCT06133036	Sacrococcygeal ...	3 Years - 18 Years	Sohag University

Spots Global Cancer Trial Database for sacrococcygeal teratoma