Neoplasms

All Conditions

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Nervous System Diseases

Symptoms and General Pathology

Carcinoma

Urinary Bladder Neoplasms

Sarcopenia

Urologic Neoplasms

Urogenital Neoplasms

Urogenital Diseases

Female Urogenital Diseases

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Female Urogenital Diseases and Pregnancy Complications

Urinary Bladder Diseases

Urologic Diseases

Male Urogenital Diseases

Atrophy

Muscular Atrophy

Neuromuscular Manifestations

Neurologic Manifestations

Pathological Conditions, Anatomical

sarcopenic status the day before cystectomy.

walking speed, grip strength and BIA. QAPPA questionnaire (validated in French in the elderly) and the objective measurement of the time of activity and rest on a week per wrist actimeter.

Comprehensive Geriatric Assessment

sarcopenia and mobility measurement

françois fournel

helene legros

Bérengère Beauplet, PhD

Emilie Nouzergues

Anne-Laure Couderc, MD

Maeva Bizon

Christian Pfister

Sarcopenia is associated with lower prognosis in solid tumors, but this has not been studied in bladder carcinoma requiring cystectomy.

According to EWGSOP recommendations, the diagnosis of sarcopenia is based on walking speed, grip strength and muscle mass. These three elements can easily be measured (specially muscle mass measurement by bioimpedencemetry or tomodensitometry).

This cohort study will collect clinical complementary elements to better understand the associated factors present with sarcopenia, in order to prepare an interventional preoperative physical reconditioning study.

The mobility measurement will be carried out by the QAPPA questionnaire (validated in French in the elderly) and the quantitative measurement of activity and rest hours during a week by a wrist actimeter.

Standardized geriatric data will also be collected: ADL, IADL for autonomy, MMSE for cognitive status, nutritional status (% weight loss, BMI), pain, GDS15 for depression screening, updated Charlson Comorbidity Index to identify polypathology and The STOPP tool for potentially inappropriate medication.

Post-operative morbidity mortality at 30 days will be evaluated according to Clavien-Dindo classification. Investigators will also evaluate 6 months geriatric complications : falls, loss of autonomy and decreased mobility and physical activity, cognitive degradation, undernutrition, institutionalization

SArcopenia, Mobility, PHYsical Activity and Post-operative Risk of Bladder Carcinoma in the Elderly

evaluated according to Clavien-Dindo classification

physical activity scores (QAPPA) Questionnaire d'activité physique pour les personnes âgées in French validated in French population - total score is used

fatigue (BFI) Brief Fatigue Inventory questionnaire

pain (visual analogic scale for pain 0 to 10)

hours of daily rest (actimetry) measured during 3 consecutives days

nutritional status (nutritional grade 2 or 4 according to SFNEP Société Francophone Nutrition Clinique et Métabolisme )

Concordance of values (attribution of sarcopenic / non-sarcopenic groups) with impedancemetric value

EORTC QLQ-ELD14 (assessment of health-related quality of life elderly patients with cancer with 14 items)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
SArcopenia, Mobility, PHYsical Activity and Post-operative Risk of Bladder Carcinoma in the Elderly	NCT03362801	Sarcopenia Bladder Cancer	sarcopenia and ...	65 Years -	University Hospital, Caen
SArcopenia, Mobility, PHYsical Activity and Post-operative Risk of Bladder Carcinoma in the Elderly	NCT03362801	Sarcopenia Bladder Cancer	sarcopenia and ...	65 Years -	University Hospital, Caen
SArcopenia, Mobility, PHYsical Activity and Post-operative Risk of Bladder Carcinoma in the Elderly	NCT03362801	Sarcopenia Bladder Cancer	sarcopenia and ...	65 Years -	University Hospital, Caen

Spots Global Cancer Trial Database for sarcopenia and mobility measurement