Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

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Urinary Bladder Neoplasms

Urologic Neoplasms

Urogenital Neoplasms

Urogenital Diseases

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Urinary Bladder Diseases

Urologic Diseases

Male Urogenital Diseases

eligible patients will undergo initial mpMRI before initial TURBT, then followed by second mpMRI and second resection TURBT after 4 weeks

all eligible patients will undergo mpMRI 4 weks after initial TURBT

mpMRI

after mpMRI all patients will subjected to second look TURBT

Second look TURBT

Amr A Elsawy, MD

Ahmed M Elshal

Amr A. Elsawy, MD

Ahmed Mosbah

The aim of the study is to prospectively assess the role of mpMRI as a non invasive method for assessment of possible residual tumor after initial resection of non muscle invasive bladder tumor.

Comprehensive multiparametric (mp) MRI which includes T2 weighted imaging, dynamic contrast enhanced (DCE) imaging and DWI, was proven to be efficient tool in differentiating benign and malignant bladder lesion. morphological characterization of malignant bladder lesion (mapping/size/morphology/stalk), T stage differentiation and histological grade discrimination.

The application of mpMRI in NMIBC with its added value as non invasive tool for initial staging and after primary resection could be a new helpful method for better diagnosis, risk categorization, refining the indications of second resection and proper determination of adjuvant treatment.

Comprehensive Multiparametric Magnetic Resonance Imaging After Transurethral Resection of Non Muscle-invasive Bladder Tumor; Can it Replace Second Look Biopsy? A Prospective Study

assessment of the performance of mpMRI as a diagnostic tool for possible residual malignancy after initial TURBT by comparing the results obtained by pre-second look TURBT mpMRI (Test of the study) with results of second look biopsy whether benign or malignant (Standard test).

Predictive capability of initial mpMRI of differentiation between benign and malignant bladder lesions.

2- Predictive capability of initial mpMRI of differentiation between NMIBC and muscle invasive disease.

Accuracy of bladder mapping in initial mpMRI (18) as a guide during TURBT.

Predictive value of initial mpMRI for characterization of NMIBC (T stage, Grading, Risk categorization).

Rate of over staging and under staging of NMIBC after second look TURBT in this prospective series.

Morbidity (using modified Dindo-Clavian system for post-operative complications (19) and mortality rates after second look TURBT.

Readmission rate after second look TURBT.

Cost comparison of mpMRI and second look TURBT.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Comprehensive Multiparametric Magnetic Resonance Imaging After Transurethral Resection of Non Muscle-invasive Bladder Tumor; Can it Replace Second Look Biopsy? A Prospective Study	NCT03914001	Bladder Cancer	mpMRI Second look TUR...	18 Years -	Mansoura University
Comprehensive Multiparametric Magnetic Resonance Imaging After Transurethral Resection of Non Muscle-invasive Bladder Tumor; Can it Replace Second Look Biopsy? A Prospective Study	NCT03914001	Bladder Cancer	mpMRI Second look TUR...	18 Years -	Mansoura University
Comprehensive Multiparametric Magnetic Resonance Imaging After Transurethral Resection of Non Muscle-invasive Bladder Tumor; Can it Replace Second Look Biopsy? A Prospective Study	NCT03914001	Bladder Cancer	mpMRI Second look TUR...	18 Years -	Mansoura University

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