Neoplasms

Digestive System Diseases

All Conditions

Colonic Neoplasms

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Herbal and Botanical

All Drugs and Chemicals

Cola

After careful mobilization of the affected colon segment, isosulfan blue 1% is injected in vivo into the subserosa circumferentially around the tumor. Lymph nodes in the mesentery staining blue within the first minutes are marked as SLN. The procedure is followed by a resection of the affected colon segment with standard lymphadenectomy.

Sentinel lymph node procedure

Prior to surgery, bone marrow is aspirated from both iliac crests. Bone marrow aspirates are analyzed for the presence of occult metastatic colon cancer cells.

Bone marrow aspiration

Carsten T. Viehl, MD

Markus Zuber, MD

The study is a feasibility and validation study of the sentinel lymph node (SLN) procedure in all stages of colon cancer. If the SLN can be reliably identified, it could be submitted to a more accurate histopathological examination (multiple sections, special staining). The detection of micrometastases in the SLN (occult stage III, upstaging) is possible. Patients with micrometastases should be considered at higher risk.

Additionally, a search for occult metastatic tumor cells in the bone marrow is performed.

Swiss Prospective, Multicenter Study Sentinel Lymph Node Procedure in Colon Cancer

University Hospital, Basel, Switzerland

Skin and Connective Tissue Diseases

Breast Neoplasms

Breast Diseases

Skin Diseases

Sentinel lymph node procedure according to the Dutch breast cancer guideline

Marjolein L Smidt, MD, PhD

Hans JW de Wilt, MD, PhD

STUDY AIM To decrease the number of breast cancer patients receiving over treatment of the axilla, in order to positively influence the axillary morbidity rate and quality of life.

PRIMARY OBJECTIVE To determine whether omitting the sentinel lymph node procedure is not inferior to the current axillary staging regimen in clinically node negative breast cancer patients undergoing breast conserving therapy, in terms of regional recurrence rate.

HYPOTHESIS The sentinel lymph node procedure can be safely omitted in clinically node negative breast cancer patients undergoing breast conserving therapy. This will lead to a decreased axillary morbidity rate, with a non-inferior regional recurrence-, distant-disease free- and overall survival rates.

Omitting Sentinel Node Procedure in Breast Cancer Patients Undergoing Breast Conserving Therapy

Clinically Node Negative Breast Cancer Patients Undergoing Breast Conserving Therapy: Sentinel Lymph Node Procedure Versus Follow-Up.

Regional recurrence is defined as tumour recurrence and as residual tumour that became clinically apparent in ipsilateral axillary, infraclavicular and supraclavicular lymph nodes (pathologically proven).

Borstkanker Onderzoek Groep

Dutch Cancer Society

Maastricht University

Maastricht University Medical Center

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Swiss Prospective, Multicenter Study Sentinel Lymph Node Procedure in Colon Cancer	NCT00826579	Colonic Neoplas...	Sentinel lymph ... Bone marrow asp...	-	University Hospital, Basel, Switzerland
Omitting Sentinel Node Procedure in Breast Cancer Patients Undergoing Breast Conserving Therapy	NCT02271828	Breast Neoplasm...	Sentinel lymph ...	18 Years -	Maastricht University Medical Center
Swiss Prospective, Multicenter Study Sentinel Lymph Node Procedure in Colon Cancer	NCT00826579	Colonic Neoplas...	Sentinel lymph ... Bone marrow asp...	-	University Hospital, Basel, Switzerland

Spots Global Cancer Trial Database for sentinel lymph node procedure