Symptoms and General Pathology

All Conditions

Neoplasms

Digestive System Diseases

Recurrence

Colorectal Neoplasms

Intestinal Neoplasms

Gastrointestinal Neoplasms

Digestive System Neoplasms

Gastrointestinal Diseases

Colonic Diseases

Intestinal Diseases

Rectal Diseases

Disease Attributes

Patients with stage I to IV colorectal cancer

Baseline blood samples, surgical resected tumor tissue, blood samples after surgery (D5-7), blood samples before adjuvant therapy and blood samples after adjuvant therapy (every 3 months for up to 2 years follow-up) will be collected from colorectal patients.

Serial ctDNA monitoring

Gong Chen, PhD

This observational study aims to assess the predictive value of postoperative circulating tumor DNA (ctDNA) monitoring in evaluating the risk of recurrence in stage I-IV colorectal cancer patients. The study involves the collection of blood samples from patients who have undergone surgery for colorectal cancer. Sensitivity-enhanced molecular biology techniques are utilized to detect ctDNA in these samples. The correlation between ctDNA detection and the risk of recurrence is evaluated by analyzing patient follow-up data and clinical information. The findings of this study may contribute to the development of improved postoperative management strategies, such as identifying high-risk individuals and implementing additional treatment measures to reduce the risk of recurrence.

Predictive Value of Postoperative Circulating Tumor DNA Monitoring for Colorectal Cancer Recurrence

The Predictive Value of Postoperative Circulating Tumor DNA Monitoring in Assessing the Risk of Recurrence in Stage I-IV Colorectal Cancer Patients, An Observational Study

To evaluate the correlation between circulating tumor DNA (ctDNA) detection and recurrence-free survival.

To assess positive rate of ctDNA minimal residual disease (MRD) test in stage III of colorectal cancer patient after surgery.

To assess time from positive ctDNA test to clinical recurrence.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Predictive Value of Postoperative Circulating Tumor DNA Monitoring for Colorectal Cancer Recurrence	NCT06143644	Colorectal Canc...	Serial ctDNA mo...	18 Years -	Sun Yat-sen University
Predictive Value of Postoperative Circulating Tumor DNA Monitoring for Colorectal Cancer Recurrence	NCT06143644	Colorectal Canc...	Serial ctDNA mo...	18 Years -	Sun Yat-sen University

Spots Global Cancer Trial Database for serial ctdna monitoring