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Healthy female urban residents in Shanghai between ages of 40-70.

Qing Lan, M.D.

A prospective cohort study is proposed to evaluate occupational and environmental risk factors for cancer among women in Shanghai, China. Approximately 75,000 women aged 40-69 who reside in eight geographically defined communities in two urban districts of Shanghai will be recruited via a community-based cancer education program. All eligible subjects will be invited by local health workers from the neighborhood health station to the clinic for an interview and selected anthropometric measurements. The interview will elicit information on demographic background, diet, lifestyle factors, medical history, lifetime occupational history and residential history for the past 20 years. In addition, the women will be asked for information on their husbands' current and usual occupations, and demographic and a few other exposure factors. A spot urine sample and 10 ml of blood will be collected from all cohort members and stored at -70 degrees C for future assays of urine metabolites and DNA and hemoglobin adducts of selected occupational and environmental carcinogens, and polymorphic genes encoding enzymes that are involved in metabolism of relevant carcinogens. Cohort members and their husbands will be followed for cancer outcomes through biennial recontact and linkage with files of the population-based Shanghai Cancer Registry, of the Shanghai Vital Statistics, and of the Shanghai Resident Registry. Medical records and pathology slides will be reviewed for all cancer cases to verify their diagnosis. Post-diagnostic blood samples will be obtained from all cohort members diagnosed with cancer during the follow-up period and stored for future methodologic and etiologic studies. The proposed initial study period is 5 years, with an average follow-up of about 3.5 years. We anticipate, however, that follow-up will continue for 10 years or more.

A prospective cohort study is proposed to evaluate occupational and environmental risk factors for cancer among women in Shanghai, China. Approximately 75,000 women aged 40-69 who reside in eight geographically defined communities in two urban districts of Shanghai will be recruited via a community-based cancer education program. All eligible subjects will be invited by local health workers from the neighborhood health station to the clinic for an interview and selected anthropometric measurements. The interview will elicit information on demographic background, diet, lifestyle factors, medical history, lifetime occupational history and residential history for the past 20 years. In addition, the women will be asked for information on their husbands' current and usual occupations, and demographic and a few other exposure factors. A spot urine sample and 10 ml of blood will be collected from all cohort members. Among participants who did not provide a blood sample, a buccal cell sample will be collected. All biological samples will be stored at -70 degrees C for future assays of genetic polymorphisms, urine metabolites and DNA and hemoglobin adducts of selected occupational and environmental carcinogenACs. Cohort members and their husbands will be followed for cancer outcomes through annual recontact and linkage with files of the population-based Shanghai Cancer Registry, of the Shanghai Vital Statistics, and of the Shanghai Resident Registry. Medical records and pathology slides will be reviewed for all cancer cases to verify their diagnosis. Post-diagnostic blood samples will be obtained from all cohort members diagnosed with cancer during the follow-up period and stored for future methodologic and etiologic studies. The proposed initial study period is 5 years, with an average follow-up of about 3.5 years. We anticipate, however, that follow-up will continue for 10 years or more.

A Prospective Cohort Study of Occupational Exposures and Cancer Risk Among Women

Any cancer incidence, selected chronic diseases and all causemortality

National Cancer Institute (NCI)

Patients were diagnosed since January 2002.

Yi-Jin Gao, MD

Xing-Wei Wang, MD

Ying Zheng, MS,MD

Liang Shi, MD,MPH

The purpose of this study is to describe the morbidity, mortality, disability and survival rate in Shanghai adolescents and children with cancer diagnosed since January 2002.

The investigators collected information of all the adolescents and children diagnosed cancer in Shanghai since January 2002, including their name, gender, the date of birth, the diagnosis date, disease diagnosis, residence address and the last follow-up time status (survival/death). The type of cancer included all malignant tumors such as Acute Lymphocytic Leukemia, Acute Myeloid Leukemia, Non-Hodgkin Lymphoma, Hodgkin Lymphoma, central nervous system tumors, Neuroblastoma, Wilms tumor and so on. Then the investigators would analyze the morbidity, mortality, disability and survival rate.

Shanghai Epidemiology Study for Adolescents and Children With Cancer

Shanghai Children's Medical Center

Shanghai Municipal Center for Disease Prevention & Control

Children's Cancer Group, China

Study title	NCT ID	Conditions	Eligibility	Organization
A Prospective Cohort Study of Occupational Exposures and Cancer Risk Among Women	NCT00342004	Lung Cancer Non-Hodgkin Lym... Breast Cancer Stomach Cancer Brain Cancer	40 Years - 70 Years	National Institutes of Health Clinical Center (CC)
Shanghai Epidemiology Study for Adolescents and Children With Cancer	NCT02959086	Childhood Cance...	0 Years - 19 Years	Children's Cancer Group, China
A Prospective Cohort Study of Occupational Exposures and Cancer Risk Among Women	NCT00342004	Lung Cancer Non-Hodgkin Lym... Breast Cancer Stomach Cancer Brain Cancer	40 Years - 70 Years	National Institutes of Health Clinical Center (CC)
Shanghai Epidemiology Study for Adolescents and Children With Cancer	NCT02959086	Childhood Cance...	0 Years - 19 Years	Children's Cancer Group, China
A Prospective Cohort Study of Occupational Exposures and Cancer Risk Among Women	NCT00342004	Lung Cancer Non-Hodgkin Lym... Breast Cancer Stomach Cancer Brain Cancer	40 Years - 70 Years	National Institutes of Health Clinical Center (CC)

Spots Global Cancer Trial Database for shanghai

Every month we try and update this database with for shanghai cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for shanghai

Every month we try and update this database with for shanghai cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for shanghai cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.