Neoplasms

Heart and Blood Diseases

Blood and Lymph Conditions

Immune System Diseases

All Conditions

Rare Diseases

Multiple Myeloma

Neoplasms, Plasma Cell

Neoplasms by Histologic Type

Hemostatic Disorders

Blood Coagulation Disorders

Vascular Diseases

Paraproteinemias

Blood Protein Disorders

Hematologic Diseases

Hemorrhagic Disorders

Lymphoproliferative Disorders

Immunoproliferative Disorders

All Drugs and Chemicals

Antibodies

Immunoglobulins

Participants will receive SIM0500 in a 28-day cycle until disease progression, intolerable toxicity, or until the participant voluntarily withdraws from trial intervention, or end of study, whichever comes first.

SIM0500

Juan Wen Wang

Yan Xu

This is an open-label, multicenter phase 1 clinical trial to evaluate the safety and tolerability, efficacy, and pharmacokinetics of SIM0500 in adult participants with Relapsed or Refractory Multiple Myeloma(RRMM). The trial is consisted of two parts, Part 1 (dose escalation) and Part 2 (dose optimization). In both parts, SIM0500 will be administered until disease progression, intolerable toxicity, withdraw of consent or end of trial.

Study of SIM0500 Alone in Participants With Relapsed or Refractory Multiple Myeloma

A Phase I First-in-human, Open-label Trial to Investigate the Safety, Tolerability, Pharmacokinetics and Preliminary Antitumor Activity of SIM0500, A Humanized GPRC5D-BCMA-CD3 Tri-specific Antibody, in Participants With Relapsed or Refractory Multiple Myeloma

Shanghai Xianxiang Medical Technology Co., Ltd.

Jiangsu Simcere Pharmaceutical Co., Ltd.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Study of SIM0500 Alone in Participants With Relapsed or Refractory Multiple Myeloma	NCT06375044	Relapsed or Ref...	SIM0500	18 Years -	Jiangsu Simcere Pharmaceutical Co., Ltd.
Study of SIM0500 Alone in Participants With Relapsed or Refractory Multiple Myeloma	NCT06375044	Relapsed or Ref...	SIM0500	18 Years -	Jiangsu Simcere Pharmaceutical Co., Ltd.

Spots Global Cancer Trial Database for sim0500

Every month we try and update this database with for sim0500 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for sim0500

Every month we try and update this database with for sim0500 cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for sim0500 cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.