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Sintilimab and chemotherapy are carried out at the same time for every 3 weeks

SintilimabCombined With Chemotherapy

Jun Zhao

This study collects stool, blood, and tumor tissue samples from patients with locally advanced esophageal cancer after receiving Sintilimab and chemotherapy to explore the efficacy and intestinal microbes of chemotherapy combined with neoadjuvant immunotherapy for locally advanced operable thoracic esophageal squamous cell carcinoma The main purpose is the relationship between its metabolites, and it will also explore the changes of intestinal flora diversity and metabolites before and after esophageal squamous cell carcinoma chemotherapy combined with immune neoadjuvant therapy

Correlation Between the Efficacy of Neoadjuvant Chemotherapy Combined With Immunotherapy of Operable Thoracic Esophageal Squamous Cell Carcinoma and the Metabolites of Intestinal Flora

Alpha-diversity of samples, that measures both the richness and diversity of species within a group, was calculated on taxa that were observed at least once.

Beta-diversity, that measures the differences in microbiome composition between groups.

Discovery of gut microbes and metabolic markers that can predict the efficacy of chemotherapy combined with neoadjuvant immunotherapy for esophageal squamous cell carcinoma

The First Affiliated Hospital of Soochow University

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Correlation Between the Efficacy of Neoadjuvant Chemotherapy Combined With Immunotherapy of Operable Thoracic Esophageal Squamous Cell Carcinoma and the Metabolites of Intestinal Flora	NCT05199649	Esophageal Squa... Intestinal Flor...	SintilimabCombi...	18 Years - 75 Years	The First Affiliated Hospital of Soochow University
Correlation Between the Efficacy of Neoadjuvant Chemotherapy Combined With Immunotherapy of Operable Thoracic Esophageal Squamous Cell Carcinoma and the Metabolites of Intestinal Flora	NCT05199649	Esophageal Squa... Intestinal Flor...	SintilimabCombi...	18 Years - 75 Years	The First Affiliated Hospital of Soochow University

Spots Global Cancer Trial Database for sintilimabcombined with chemotherapy