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Enrolled patients with lung cáncer will undergo home sleep testing during their initial oncologic evaluation, prior to treatment.

Sleep testing

Luis M Seijo, MD, PhD

The study seeks to determine the prevalence of sleep disordered breathing in a population of patients diagnosed with lung cáncer.

Obstructive sleep apnea hypopnea syndrome (OSAHS) is an important medical condition which causes significant morbidity and mortality. The prevalence of OSAHS in Spain is 4-6% in men and 2-4% in women and rises steadily with age. Snoring and smoking have been independently linked, and smoking may be a risk factor for developing OSAHS. This is particularly true of heavy smokers (\> 2 packs/day), those at greatest risk for LC. Associations between OSAHS and some forms of cancer have been described in humans, especially in those experiencing nocturnal hypoxemia, and intermittent hypoxia has been linked to the progression of cancer in animal models. LC is currently the leading cause of cancer deaths in developped nations. A link between OSAHS and LC, therefore, is plausible.

Sleep disordered breathing may be common among patients recently diagnosed of lung cancer and may contribute to tumor progression.

Objectives: a) To perform home sleep testing in patients recently diagnosed with lung cancer in order to determine the prevalence of sleep disordered breathing in this patient population. b) To include biological samples obtained from all participants, including surgically treated patients with stage I / IIp LC through the program in the CIBERES Pulmonary Biobank Platform. Biological samples will be preserved under different storage conditions for subsequent determination of molecular biomarkers. c) To follow-up lung cancer patients with and without sleep disordered breathing in order to determine the potential influence OSAHS might have on their prognosis.

Prospective screening for sleep disordered breathing will be performed by home sleep testing in 100 subjects diagnosed with lung cancer, irrespective of stage at diagnosis, who give their consent. A modified epidemiologic questionnaire for sleep disordered breathing will also be administered. Patients identified as suffering from OSAHS will be referred to sleep clinic. Biologic samples and lung function studies will be obtained in all participating patients.

All patients with lung cancer will undergo follow-up for at least three years or until their demise, and those identified with OSAHS will also be followed in sleep clinic. The prevalence of OSAHS in this patient population will be determined. A link between OSAHS, and especially intermittent nocturnal hypoxemia, and tumor progression will be sought.

Sleep Apnea in Lung Cancer: A Prospective Study

Prevalence of Sleep Apnea in Lung Cancer

Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz

Attending physician

Rare Diseases

Carcinoma, Non-Small-Cell Lung

Sleep Apnea, Obstructive

Small Cell Lung Carcinoma

Small Cell Lung Cancer

CPAP

Mark Fuster, MD

Sleep-disordered breathing at night is a common medical problem. It leads to daytime fatigue, impairment in concentration and daily activities, and a higher risk of cardiovascular disease and life-threatening events. A particularly common form is obstructive sleep apnea (OSA), and it is usually treatable with a high rate of patient satisfaction and improved quality of life using a continuous positive airway pressure (CPAP) device.

Treatment of this condition improves nighttime low-oxygen levels by ensuring patency of the upper airways. Research shows that in cancer, sleep disordered breathing is frequent. Low oxygen levels overnight may cause tumors to grow: tumors deprived of oxygen grow more blood vessels to try to get more oxygen, and growing more blood vessels makes the tumor grow. This study aims to examine how treating sleep-disordered breathing may lessen blood-flow to lung tumors, and thus serve to ultimately block tumor growth.

Participants of this study will undergo sleep study and receive CPAP therapy as a part of routine care.

Early Diagnosis and Treatment of Sleep Disordered Breathing in Lung Cancer

maximum attenuation value (MAV) detected by perfusion-CT imaging

Mark M. Fuster, MD

Associate Professor of Medicine

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Sleep Apnea in Lung Cancer: A Prospective Study	NCT02764866	Lung Cancer Sleep-Disordere...	Sleep testing	18 Years - 85 Years	Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Early Diagnosis and Treatment of Sleep Disordered Breathing in Lung Cancer	NCT03443908	Lung Cancer	CPAP	18 Years -	University of California, San Diego
Early Diagnosis and Treatment of Sleep Disordered Breathing in Lung Cancer	NCT03443908	Lung Cancer	CPAP	18 Years -	University of California, San Diego

Spots Global Cancer Trial Database for sleep disordered breathing