Wounds and Injuries

All Conditions

Nervous System Diseases

Symptoms and General Pathology

Neoplasms

Musculoskeletal Diseases

Spinal Cord Injuries

Paralysis

Ischemia

Spinal Cord Neoplasms

Spinal Neoplasms

Central Nervous System Neoplasms

Nervous System Neoplasms

Spinal Cord Diseases

Central Nervous System Diseases

Bone Neoplasms

Bone Diseases

Spinal Diseases

Anti-Infective Agents

All Drugs and Chemicals

Minocycline

Anti-Bacterial Agents

placebo

Benjamim Drenger, Prof.

Spinal cord trauma and the consequent paraplegia are possibly among the most devastating injuries in soldiers and during spine surgery, and are significant in the medical, social and financial aspects. Limited mobility, the need for assistance in all human activities, shame, and many medical complications related directly to the neural deficits make paraplegia an important target for prevention. Our study will evaluate the efficacy of Minocycline in two different groups:

1. Minimizing the neurological damage among trauma patients.
2. Preventing neurological damage through operation in spinal tumors patients.

2.OBJECTIVES

The primary objectives of the trial are to determine:

1. Efficacy of administrating minocycline in minimizing the neurological damage among acute spinal cord injury patients and spinal cord tumors (primary and metastases) patients?
2. Efficacy of administrating minocycline at changing the natural history and rehabilitation of spinal cord trauma patients.
3. Safety of applying minocycline in spinal cord injuries patients and spinal cord tumors?

Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement

The Efficacy will be evaluated using the following measures:

1. ASIA SCORE - We will compare the results before administrating the study medication and after six months of follow up. The ASIA score will be the Primary Efficacy Endpoint.
2. The Spinal Cord Independence Measure and Functional Independence Measure outcome scales.
3. Objective reduction in lesion size by imaging modalities

Safety will be evaluated in a descriptive manner by recording all adverse events in the patient population by number and severity.

The study will evaluate safety by assessing:

* Procedure related adverse events:
* General adverse events: Adverse events not only directly related to the procedure, such as: complications related to anesthesia, hospitalization, or other general adverse events of unknown cause.

Hadassah Medical Organization

Associate Professor of Anesthesia, Director, Orthopedic Anesthesia,

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement	NCT01813240	Spinal Tumors, ...	Minocycline placebo	18 Years - 65 Years	Hadassah Medical Organization
Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement	NCT01813240	Spinal Tumors, ...	Minocycline placebo	18 Years - 65 Years	Hadassah Medical Organization

Spots Global Cancer Trial Database for spinal tumors, trauma patients, minocycline.