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Pre-Surgery SABR: Treatment with Stereotactic Ablative Body Radiation Therapy (SABR) followed by breast-conserving surgery. The usual treatment for patients with early-stage breast cancer who have breast-conserving treatment (BCT) is to receive radiotherapy AFTER surgery, targeting either the whole breast or part of the breast.

SABR will be delivered over 3 days, prior to surgery.

Standard of Care Schedule Variation: SABR

Breast-conserving surgery will be scheduled for 6-8 weeks after SABR and will be conducted by a Moffitt breast surgeon.

Breast-conserving Surgery

Michael Montejo

This study involves a course of radiation to the tumor that is delivered BEFORE surgery. The type of radiation is called stereotactic ablative body radiation therapy (SABR). The purpose of this study is to evaluate the effects, good and/or bad, of pre-operative SABR specifically focusing on its ability to reduce the chances that additional breast surgery will be needed, reducing the amount of breast/heart/lung tissue that is irradiated, and to study the tumor-tissue effects of SABR. The usual treatment for patients with early-stage breast cancer who have breast-conserving treatment (BCT) is to receive radiotherapy AFTER surgery, targeting either the whole breast or part of the breast.

Preoperative Stereotactic Ablative Body Radiotherapy (SABR) for Early-Stage Breast Cancer

A Phase II Study of Preoperative Stereotactic Ablative Body Radiotherapy (SABR) for Early-Stage Breast Cancer: Introduction of a Novel Form of Accelerated Partial Breast Radiotherapy

Rate of pathologic complete response following pre-operative SABR for early-stage breast carcinoma. pCR: The absence of residual invasive disease in the breast and in the axillary lymph nodes at the completion of the neoadjuvant treatment.

H. Lee Moffitt Cancer Center and Research Institute

All participants who received Stereotactic Ablative Body Radiotherapy (SABR) prior to breast surgery

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Preoperative Stereotactic Ablative Body Radiotherapy (SABR) for Early-Stage Breast Cancer	NCT03137693	Breast Cancer Breast Cancer F... Breast Adenocar...	Standard of Car... Breast-conservi...	50 Years -	H. Lee Moffitt Cancer Center and Research Institute
Preoperative Stereotactic Ablative Body Radiotherapy (SABR) for Early-Stage Breast Cancer	NCT03137693	Breast Cancer Breast Cancer F... Breast Adenocar...	Standard of Car... Breast-conservi...	50 Years -	H. Lee Moffitt Cancer Center and Research Institute

Spots Global Cancer Trial Database for standard of care schedule variation: sabr