Infections

All Conditions

Symptoms and General Pathology

Neoplasms

Communicable Diseases

Abdominal Neoplasms

Intraabdominal Infections

The patients with ScvO2 ≥ 70% will receive the conventional fluid therapy.than collect the data of ScvO2 and Pcv-aCO2:

ScvO2≥70%，and furthermore, Pcv-aCO2 is divided into "≤6mmHg" and "\>6mmHg"

The patients with ScvO2 \<70% will receive the standardized fluid therapy for 6 hours.than collect the data of ScvO2 and Pcv-aCO2:

ScvO2\<70%，and furthermore, Pcv-aCO2 is divided into "≤6mmHg" and "\>6mmHg"

The patients with ScvO2 \<70% will receive the standardized fluid therapy for 6 hours.

standardized fluid therapy

The patients with ScvO2 ≥ 70% will receive the conventional fluid therapy.

conventional fluid therapy

Yang Yang, physician

Yang Lu, physician

Wanhua Wang, director

This research will confirm that Pcv-aCO2 is suitable for the guidance of early fluid therapy and the evaluation of the prognosis of patients with abnormal hemodynamics after abdominal tumor surgery, and is expected to be a new monitoring index to improve the therapeutic effect of these patients.

1. Confirmed that Pcv-aCO2 is suitable for the guidance of early fluid therapy and the evaluation of the prognosis of patients with abnormal hemodynamics after abdominal tumor surgery, and is expected to be a new monitoring index to improve the therapeutic efficacy of this kind of patients.
2. Pcv-aCO2 effectively reflected the improvement of tissue and organ microcirculation disorder through the individual goal target treatment to guide the fluid resuscitation in the hemodynamic instability patients.
3. Research of the correlation between Pcv-aCO2 and the organ function in patients with abnormal hemodynamics after operation.

Evaluation of Pcv-aCO2 in the Fluid Treatment of Abdominal Tumor Patients After Surgery

Clinical Study of Central Venous-to-Arterial Carbon Dioxide Difference(Pcv-aCO2) in the Evaluation of Fluid Therapy for Postoperative Patients With Abdominal Cancer

The change of Central venous oxygen saturation (ScvO2, %)after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

The change of hemoglobin (Hb, g/L) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

The change of blood lactic acid (Lac, mmol/L) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

The change of Cardiac Index (CI, L/(min•m\^2)) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

Collect the index of oxygen supply (DO2, ml/(min•m\^2)) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

Collect the index of oxygen consumption (VO2, ml/(min•m\^2)) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

The change of Pcv-aCO2 (mmHg) after fluid resuscitation for 6 hours, 12 hours and 24 hours respectively.

Collect the index of treatment success rate(%) of patients in different groups.

Collect the index of 28 day mortality(%) of patients in different groups.

Collect the index of hospitalization course(days) of patients in different groups.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Evaluation of Pcv-aCO2 in the Fluid Treatment of Abdominal Tumor Patients After Surgery	NCT02977429	Abdominal Tumor Abdominal Infec...	standardized fl... conventional fl...	18 Years - 65 Years	Tianjin Medical University Cancer Institute and Hospital
Evaluation of Pcv-aCO2 in the Fluid Treatment of Abdominal Tumor Patients After Surgery	NCT02977429	Abdominal Tumor Abdominal Infec...	standardized fl... conventional fl...	18 Years - 65 Years	Tianjin Medical University Cancer Institute and Hospital

Spots Global Cancer Trial Database for standardized fluid therapy