Symptoms and General Pathology

All Conditions

Respiratory Tract (Lung and Bronchial) Diseases

Constriction, Pathologic

Airway Obstruction

Respiratory Insufficiency

Respiration Disorders

Respiratory Tract Diseases

give the cases whose central airway stricture were caused by soft neoplasm tissues cryotherapy

give the cases whose central airway stricture were caused by hard neoplasm tissues argon plasma coagulation

give the cases whose central airway stricture were caused by neoplasm compression stent placement

give the cases whose central airway stricture were caused by polypoid neoplasm tissues snare

use cryotherapy to delete soft neoplasm tissue in the airway

cryotherapy

use argon plasma coagulation to delete hard neoplasm tissue in the airway

argon plasma coagulation

use stent placement to open the airway compressed by out neoplasm

stent placement

use snare to delete polypoid neoplasm tissue in the airway

deletion tumor tissue by snare

Deguang Mu, Ph.D

Yandong Nan, MD

Faguang Jin, Ph.D

The purpose of this study is to evaluate the efficacy and safety of four interventional pulmonology techniques for the treatment of malignant central airway stricture.

The four techniques are：

* cryotherapy
* argon plasma coagulation
* stent
* snare

Study of Interventional Pulmonologic Treatment of Malignant Central Airway Stricture

Prospective, Open, Multicenter Study of Interventional Pulmonologic Treatment of Malignant Central Airway Stricture

Changhai Hospital

The First Affiliated Hospital of Guangzhou Medical University

Xinqiao Hospital of Chongqing

China Meitan General Hospital

Micro-Tech (Nanjing) Co., Ltd.

Tang-Du Hospital

Neoplasms

Digestive System Diseases

Gland and Hormone Related Diseases

Rare Diseases

Pancreatic Neoplasms

Pancreatic Cancer

Endoscopic retrograde cholangiopancreatogram (ERCP) is performed under standard conditions with cannulation of the bile duct, and demonstration on a cholangiogram the location, diameter and length of the biliary stricture. The HabibTM EndoHBP probe (EMcision, London, United Kingdom) is advanced through the working channel of a side viewing endoscope over a 0.035in guidewire, and positioned across the occluded SEMS under fluoroscopy. 7-10W are usually delivered for 90 seconds with a standard high frequency generator, followed by a 1 minute resting period. Sequential applications of RFA are applied along the entire length of the stricture with an overlap of 1cm.

Endoscopic retrograde cholangiopancreatogram (ERCP) is performed under standard conditions with cannulation of the bile duct, and demonstration on a cholangiogram the location, diameter and length of the biliary stricture. The HabibTM EndoHBP probe (EMcision, London, United Kingdom) is advanced through the working channel of a side viewing endoscope over a 0.035in guidewire, and positioned across the occluded SEMS under fluoroscopy. 7-10W are usually delivered for 90 seconds with a standard high frequency generator, followed by a 1 minute resting period.

ERCP with SEMS plus radiofrequency ablation

ERCP with SEMS alone (standard of care)

Mark Schattner, MD

The purpose of this study is to compare the effects good and/or bad of combining radiofrequency ablation with placement of a second stent, versus a second stent alone. The investigators will also look at the safety of the combination treatment, and see which treatment is better. In either case, the second stent will be placed inside the existing stent as is done in standard practice when treating a blocked stent for the first time.

Endoscopic Biliary Co-axial Stent Placement Plus/Minus Use of Radiofrequency Ablation (RFA) for Clearance of Occluded Self Expandable Metal Stents (SEMS) in Patients With Distal Biliary Obstruction From Unresectable Biliary-pancreatic Malignancies

A Randomized Trial of Endoscopic Biliary Co-axial Stent Placement Plus/Minus Use of Radiofrequency Ablation (RFA) for Clearance of Occluded Self Expandable Metal Stents (SEMS) in Patients With Distal Biliary Obstruction From Unresectable Biliary-pancreatic Malignancies

Memorial Sloan Kettering Cancer Center

Endoscopic retrograde cholangiopancreatogram (ERCP) is performed under standard conditions with cannulation of the bile duct, and demonstration on a cholangiogram the location, diameter and length of the biliary stricture. The HabibTM EndoHBP probe (EMcision, London, United Kingdom) is advanced through the working channel of a side viewing endoscope over a 0.035in guidewire, and positioned across the occluded SEMS under fluoroscopy. 7-10W are usually delivered for 90 seconds with a standard high frequency generator, followed by a 1 minute resting period. Sequential applications of RFA are applied along the entire length of the stricture with an overlap of 1cm.

ERCP with SEMS plus radiofrequency ablation

ERCP With SEMS Plus Radiofrequency Ablation

Endoscopic retrograde cholangiopancreatogram (ERCP) is performed under standard conditions with cannulation of the bile duct, and demonstration on a cholangiogram the location, diameter and length of the biliary stricture. The HabibTM EndoHBP probe (EMcision, London, United Kingdom) is advanced through the working channel of a side viewing endoscope over a 0.035in guidewire, and positioned across the occluded SEMS under fluoroscopy. 7-10W are usually delivered for 90 seconds with a standard high frequency generator, followed by a 1 minute resting period.

ERCP with SEMS alone (standard of care)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Study of Interventional Pulmonologic Treatment of Malignant Central Airway Stricture	NCT02299830	Airway Obstruct...	cryotherapy argon plasma co... stent placement deletion tumor ...	18 Years - 70 Years	Tang-Du Hospital
Endoscopic Biliary Co-axial Stent Placement Plus/Minus Use of Radiofrequency Ablation (RFA) for Clearance of Occluded Self Expandable Metal Stents (SEMS) in Patients With Distal Biliary Obstruction From Unresectable Biliary-pancreatic Malignancies	NCT02340728	Pancreatic Canc... Unresectable Bi...	ERCP with SEMS ... ERCP with SEMS ...	18 Years -	Memorial Sloan Kettering Cancer Center
Study of Interventional Pulmonologic Treatment of Malignant Central Airway Stricture	NCT02299830	Airway Obstruct...	cryotherapy argon plasma co... stent placement deletion tumor ...	18 Years - 70 Years	Tang-Du Hospital
Endoscopic Biliary Co-axial Stent Placement Plus/Minus Use of Radiofrequency Ablation (RFA) for Clearance of Occluded Self Expandable Metal Stents (SEMS) in Patients With Distal Biliary Obstruction From Unresectable Biliary-pancreatic Malignancies	NCT02340728	Pancreatic Canc... Unresectable Bi...	ERCP with SEMS ... ERCP with SEMS ...	18 Years -	Memorial Sloan Kettering Cancer Center

Spots Global Cancer Trial Database for stent placement