Neoplasms

Symptoms and General Pathology

All Conditions

Neoplasm Metastasis

Pain

Neoplastic Processes

Central Nervous System Depressants

All Drugs and Chemicals

Vasodilator Agents

Anesthetics

Polymethyl Methacrylate

Vertebroplasty followed by Stereotactic Body Radiation Therapy (SBRT)

SBRT consists of radiotherapy treatments hypofractionated in 1 to 5 fractions, at doses considered curative at a precise target volume.

The vertebroplasty will be performed according to the usual procedure at the center in the angiography suite under local anesthesia and conscious sedation

* Introduction of a vertebral needle, under biplanar fluoroscopic guidance, polymethylmethacrylate (PMMA) cement injection.
* Cone-beam volume-CT at the end of the procedure, with the angiography table and c-arm, to evaluate the cement distribution and detect any leak.
* Decubitus position for 2 hours following procedure, then hospital discharge on the same day.

Vertebroplasty

SBRT consists of radiotherapy treatments hypofractionated in 1 to 5 fractions, at doses considered curative at a precise target volume

Stereotactic Body Radiation Therapy only

Véronique Freire, MD

Fidaa Al-Shakfa, M.sc.

Veronique Freire, MD

Mom PHAT

Laura Masucci, MD

David Donath, MD

David Roberge, MD

Taussky Daniel, MD

Shedid Daniel, MD

Sung-Joo Yuh, MD

Zhi Wang, MD

The goal of treating metastases is to preserve stability and neurological function while reducing pain. The actual standard of care is stereotaxic body radiation therapy (SBRT) alone in non-surgical patients. The added value of vertebroplasty to SBRT is not well documented in the literature, nor whether performing vertebroplasty before radiotherapy treatment leads to a reduction in the rate of fractures and post-SBRT pain.

Increased Early Pain Relief by Adding Vertebroplasty to SBRT

Pre-irradiation Vertebroplasty in Patients With Spine Metastases Candidates for SBRT vs SBRT Alone: Increased Early Pain Relief

Visual Analogue Scale, from 0 to 10, 10 being the highest pain

EORTC Quality of life Questionnaire : QLQ-C30 (score between 0 and 100, highest numbers represents higher response and quality of life)

QLQ-Bone metastases : BM22 questionnaire (All of the scales range in score from 0 to 100. A high score for the symptom scales represents a high level of symptomatology or problems, whilst a high score for the functional scales represents a high level of functioning)

Karnofsky performance scale (score from 0 to 100, the lower the Karnofsky score, themore disable the patient is and need assistance)

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Increased Early Pain Relief by Adding Vertebroplasty to SBRT	NCT05317026	Spine Metastase... Radiation Thera... Pain	Vertebroplasty Stereotactic Bo...	18 Years -	Centre hospitalier de l'Université de Montréal (CHUM)
Increased Early Pain Relief by Adding Vertebroplasty to SBRT	NCT05317026	Spine Metastase... Radiation Thera... Pain	Vertebroplasty Stereotactic Bo...	18 Years -	Centre hospitalier de l'Université de Montréal (CHUM)

Spots Global Cancer Trial Database for stereotactic body radiation therapy only