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SRT or CRT is radiation delivered precisely conforming the high dose region to the tumor, usually in a few highdose fractions.

Stereotactic radiotherapy (SRT) or highly conformal (CRT)

Laura Dawson, MD

A minority of patients with colorectal liver metastases and hepatobiliary cancer (primary liver cancer) are candidates for surgery, but there are no curative treatment options for these patients. Their median survival time is 3 to 12 months. Stereotactic radiation (SRT) (highly conformal radiotherapy (CRT)) is a treatment option for these patients with unresectable liver cancer, now possible due to improvements in our ability to localize and immobilize liver tumors and an improved understanding of the partial liver volume tolerance to radiation. SRT should permit liver tumors to be treated to tumorcidal doses while sparing the uninvolved liver, decreasing the risk of treatment related normal tissue toxicity. With such conformal radiation, it is possible to deliver radiation in fewer fractions than traditionally required, which should be more convenient for patients. In this study, CRT will be delivered during shallow breathing or breath hold to minimize organ motion due to breathing, decreasing the volume of normal liver that must be irradiated.

Stereotactic Radiotherapy (SRT) Liver (COLD 1)

Phase I/II Trial of Highly Conformal Radiotherapy for Unresectable Liver Metastases and Hepatobiliary Carcinoma

American Society of Clinical Oncology

University Health Network, Toronto

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Stereotactic Radiotherapy (SRT) Liver (COLD 1)	NCT00152906	Liver Neoplasms Neoplasm Metast...	Stereotactic ra...	18 Years -	University Health Network, Toronto
Stereotactic Radiotherapy (SRT) Liver (COLD 1)	NCT00152906	Liver Neoplasms Neoplasm Metast...	Stereotactic ra...	18 Years -	University Health Network, Toronto

Spots Global Cancer Trial Database for stereotactic radiotherapy (srt) or highly conformal (crt)