Neoplasms

Heart and Blood Diseases

Blood and Lymph Conditions

Immune System Diseases

All Conditions

Symptoms and General Pathology

Rare Diseases

Multiple Myeloma

Neoplasms, Plasma Cell

Leukemia

Smoldering Multiple Myeloma

Leukemia, Plasma Cell

Neoplasms by Histologic Type

Hemostatic Disorders

Blood Coagulation Disorders

Vascular Diseases

Paraproteinemias

Blood Protein Disorders

Hematologic Diseases

Hemorrhagic Disorders

Lymphoproliferative Disorders

Immunoproliferative Disorders

Precancerous Conditions

Hypergammaglobulinemia

Plasma Cell Leukemia

Subjects with Monoclonal Gammopathy of Undetermined Significance (MGUS), smouldering Multiple Myeloma (SMM), Multiple Myeloma (MM), Plasma Cell Leukemia (PCL)

Timepoints and samples to be collected are the following:

* bone marrow aspirate, bone marrow biopsy, EMD biopsy, peripheral blood and serum at baseline;
* bone marrow aspirate, bone marrow biopsy, peripheral blood and serum pre-maintenance in TE patients or after 1 year of therapy in Non-Transplant-Eligible (NTE) patients;
* bone marrow aspirate, bone marrow biopsy, peripheral blood and serum during maintenance therapy and only if performed as SOC;
* bone marrow aspirate, bone marrow biopsy, EMD biopsy peripheral blood and serum at 1st and later PD.

storage of biological samples

Antonella Balsamo

Schmitt

Strassl

Krauth

Mikula

Wrobel

Minařík

Stejskal

Hajek

Kessler

Pavlicek

Terpos

Katodrytou

Monaco

Offidani

Cavo

Belotti

Derudas

Antonioli

Aquino

Allegra

Palmieri

Casaluci

Zambello

Mangiacavalli

Martelli

Falcone

Liberati

D'Agostino

Francesca Patriarca

Bila

This is an observational, non-interventional, multicenter study for the prospective collection, storage and analysis of patients' biological samples.

This study establishes a common international infrastructure useful to collect standard clinical variables at baseline and during treatment and to uniformly collect and store biological samples

* bone marrow aspirate, bone marrow biopsy, extramedullary disease (EMD) biopsy, peripheral blood and serum at baseline;
* bone marrow aspirate, bone marrow biopsy, peripheral blood and serum pre-maintenance in TE patients or after 1 year of therapy in non transplant eligible patients;
* bone marrow aspirate, bone marrow biopsy, peripheral blood and serum during maintenance therapy and only if performed as standard of care (SOC);
* bone marrow aspirate, bone marrow biopsy, EMD biopsy peripheral blood and serum at 1st and later progressive disease (PD).

European Myeloma Network (EMN) Sample Project

EMN Prospective Sample Collection Project

Collect biological samples for research studies related to improving medicine and care to the patient

Janssen, LP

Stichting European Myeloma Network

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
European Myeloma Network (EMN) Sample Project	NCT06237803	Multiple Myelom... Smoldering Mult... Plasma Cell Leu... Extramedullary ... MGUS	storage of biol...	18 Years -	Stichting European Myeloma Network
European Myeloma Network (EMN) Sample Project	NCT06237803	Multiple Myelom... Smoldering Mult... Plasma Cell Leu... Extramedullary ... MGUS	storage of biol...	18 Years -	Stichting European Myeloma Network

Spots Global Cancer Trial Database for storage of biological samples