Heart and Blood Diseases

All Conditions

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Symptoms and General Pathology

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Heart Diseases

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Disease Progression

Carcinoid Tumor

Carcinoid Heart Disease

Neuroectodermal Tumors

Neuroectodermal Tumors, Primitive

Neoplasms, Germ Cell and Embryonal

Neoplasms by Histologic Type

Neoplasms, Nerve Tissue

Adenocarcinoma

Carcinoma

Neoplasms, Glandular and Epithelial

Syndrome

Malignant Carcinoid Syndrome

Serotonin Syndrome

Neuroendocrine Tumor

Neuroepithelioma

Carcinoid Syndrome

* Adult patients with well-differentiated metastatic ileum or bronchial neuroendocrine tumor
* Adult patients with carcinoid syndrome or elevated urinary 5HIAA regardless of primary site

Patient at high risk of Carcinoid Heart Disease (metastatic ileum or bronchial well-differentiated neuroendocrine tumors, patients with high level of urinary 5HIAA or with carcinoid syndrome) are followed with annual echocardiography to detect the occurrence of carcinoid heart disease.

In case of documented Carcinoid Heart Disease, a six or three months' cardiac follow-up is necessary to evaluate the progression and the severity of the disease.

Investigators collect the data of clinical parameters (flushes, diarrhea, ...) biological parameters (urinary 5HIAA, NT-ProBNP ...) and cardiac parameters that may influence the occurrence, severity and progression of Carcinoid Heart Disease.

Study of the occurrence of Carcinoid Heart Disease

Catherine LOMBARD-BOHAS, Dr

Laurent FRANCOIS, Dr

Carcinoid Heart Disease (CHD) is a rare form of heart disease, occurring in over 50% of the patients with carcinoid syndrome. Pathophysiology, prognostic factors of development of Carcinoid Heart Disease and progression of disease remain unclear.

This observational multicenter cohort study is designed to study the occurrence of Carcinoid Heart Disease in patients with differentiated carcinoid tumors, to describe numerous factors influencing the occurrence, severity, progression and long-term survival of patients with Carcinoid Heart Disease. Basic informations and detailed diagnosis informations (oncological and cardiac parameters), are collected by professional doctors. Clinical outcomes (onset of Carcinoid Heart Disease, cardiac surgery, related death) will be followed up every year or every six/three months if clinically indicated.

Development and Progression of Carcinoid Heart Disease in a Cohort of Adult Patients With Neuroendocrine Tumors

Development and Progression of Carcinoid Heart Disease in a Cohort of Adult Patients With Neuroendocrine Tumors Carcinoid Heart Disease (CHD): An Observational French Multi-Centre Cohort Study CRUSOE - NETs (CaRdiac UltraSonic OutcomEs - NETs)

Percentage of patients with carcinoid heart disease at diagnosis and during follow-up (carcinoid heart disease diagnosis will be assessed by an annual echocardiography).

Percentage of patients requiring cardiac surgery for the cardiac carcinoid heart disease

Correlation between urinary 5HIAA levels at diagnosis and occurrence of carcinoid heart disease

Overall survival in patents with and without carcinoid heart disease

Hospices Civils de Lyon

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Development and Progression of Carcinoid Heart Disease in a Cohort of Adult Patients With Neuroendocrine Tumors	NCT03498040	Carcinoid Heart...	Study of the oc...	18 Years -	Hospices Civils de Lyon
Development and Progression of Carcinoid Heart Disease in a Cohort of Adult Patients With Neuroendocrine Tumors	NCT03498040	Carcinoid Heart...	Study of the oc...	18 Years -	Hospices Civils de Lyon
Development and Progression of Carcinoid Heart Disease in a Cohort of Adult Patients With Neuroendocrine Tumors	NCT03498040	Carcinoid Heart...	Study of the oc...	18 Years -	Hospices Civils de Lyon

Spots Global Cancer Trial Database for study of the occurrence of carcinoid heart disease