Neoplasms

Nervous System Diseases

All Conditions

Central Nervous System Neoplasms

Nervous System Neoplasms

Subjects undergo indocyanine green injection within 72 hours prior to surgery. Permitting infusion time within 72 hours of operation is believed to be adequate for tissue glow/surgical visualization. Alternately, patients may receive 25 mg of indocyanine green during induction. Dose and time of administration will be determined by the neurosurgeon during surgical planning. This 25 mg dose of indocyanine green is similar to dosing for other intraoperative vascular visualization.

Indocyanine Green (ICG)

Intraoperative near-infrared (NIR)

John Lee, MD

This study is a single center, open-label, two-part study to assess image guided surgery of intramolecular imaging in nervous system tumors. Subjects with a diagnosis of a resectable nervous system tumor who are at risk of recurrence are included. The primary goal is to observe what tissues fluoresce in the OR, and then to identify if that tissue is cancerous/tumor or normal when the histopathology is performed.

Indocyanine Green for Central Nervous System Tumors

A Pilot/Feasibility Study of Intraoperative Image-Guided Surgery of CNS Tumors With Indocyanine Green and MR Spectroscopic Imaging

sensitivity of delayed, high dose indocyanine green (second window ICG), as measured by the signal-to-background ratio (SBR)

Abramson Cancer Center at Penn Medicine

ICG Arm

Age, Continuous

Sex: Female, Male

Race and Ethnicity were not collected from any participant.

Race and Ethnicity Not Collected

United States

Region of Enrollment

Marie Kerr, Project Manager

Sensitivity (SBR)

Overall Study

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Indocyanine Green for Central Nervous System Tumors	NCT02710240	Suspected Centr...	Indocyanine Gre... Intraoperative ...	18 Years -	Abramson Cancer Center at Penn Medicine
Indocyanine Green for Central Nervous System Tumors	NCT02710240	Suspected Centr...	Indocyanine Gre... Intraoperative ...	18 Years -	Abramson Cancer Center at Penn Medicine

Spots Global Cancer Trial Database for suspected central nervous system tumors