Respiratory Tract (Lung and Bronchial) Diseases

All Conditions

Neoplasms

Blood and Lymph Conditions

Rare Diseases

Respiratory Insufficiency

Hematologic Neoplasms

Hematologic Diseases

Respiration Disorders

Respiratory Tract Diseases

Acute Graft Versus Host Disease

Retrospective study of ICU admissions of hematology patients for respiratory and hemodynamic reasons Time period: January 2012 to March 2017

Corresponding to the period after the implementation of a systematic intensivist evaluation Daily screening of systolic blood pressure, oxygen saturation and oxygen requirements of all patients hospitalized in hematology wards. Systematic evaluation of any patient presenting the inclusion criteria by an intensivist and collegial care planning.

Time period: From March 2017 to end of study

implementation of a standardized procedure for patient care in ICU

Systematic evaluation by an intensivist

Nicolas Terzi

Over the last two decades, the number of patients with hematological malignancies (HMs) admitted to the ICU increased and their mortality has dropped sharply. Patients with HMs increasingly require admission to the intensive care unit (ICU) for life-threatening events related to the malignancy and/or treatments, with immunosuppression being a major contributor. Whether the increase in ICU admissions is related to increased referrals by hematologists and/or to increased admissions by intensivists is unknown. The criteria used for ICU referral and admission decisions have not been extensively evaluated. Finally, the links between admission policies and treatment-limitation decisions are unclear, but ICUs with broad admission policies may change the treatment goals based on the response to several days of full-code management.

The aim of this study is to evaluate the impact of a systematic evaluation by an intensivist of HMs patients presenting with acute respiratory and/or hemodynamic failure.

Systematic Evaluation by an Intensivist of Hematological Malignancy Patients Presenting With Acute Respiratory or Hemodynamic Failure

Systematic Evaluation by an Intensivist of Hematological Malignancy Patients Presenting With Acute Respiratory or Hemodynamic Failure: Impact on Prognosis: A Monocentric Observational Before-after Study

difference between the Sepsis-related Organ Failure Assessment score between 48h and 72h after ICU admission and the SOFA score during the first 24h.

SOFA score ranges from 0 to 20 delta SOFA= SOFA day 3 - SOFA day1

survival status (alive/dead) at one year after ICU admission

survival status (alive/dead) at the end of the ICU stage

survival status (alive/dead) at the end of the hospitalization

Delay between the start of critical care illness and ICU admission Delay is measured in minutes

Number of days with mechanical ventilation

Number of days with non-invasive ventilation

Number of days with renal replacement therapy

status of hematological primary disease at death or after one year of evolution if the patient is still alive. Possible status of hematology disease : complete remission, partial remission, stability, relapsed/refractory.

EQ5-D assessment of patients' quality of life one year after Intensive care unit admission

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Systematic Evaluation by an Intensivist of Hematological Malignancy Patients Presenting With Acute Respiratory or Hemodynamic Failure	NCT03399149	Respiratory Ins... Hematologic Mal...	Systematic eval...	18 Years -	University Hospital, Grenoble
Systematic Evaluation by an Intensivist of Hematological Malignancy Patients Presenting With Acute Respiratory or Hemodynamic Failure	NCT03399149	Respiratory Ins... Hematologic Mal...	Systematic eval...	18 Years -	University Hospital, Grenoble

Spots Global Cancer Trial Database for systematic evaluation by an intensivist