Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

All Conditions

Prostatic Neoplasms

Genital Neoplasms, Male

Urogenital Neoplasms

Genital Diseases

Genital Diseases, Male

Urogenital Diseases

Prostatic Diseases

Male Urogenital Diseases

Analgesics

Central Nervous System Depressants

All Drugs and Chemicals

Morphine

Analgesics, Opioid

Narcotics

The postoperative pain management includes both the intrathecal morphine injection and the intravenous patient-controlled analgesia.

The postoperative pain management includes only the intravenous patient-controlled analgesia.

The intravenous injection of morphine using the patient-controlled analgesia machine

The intravenous patient-controlled analgesia

A single injection of morphine intrathecally

The intrathecal morphine injection

Deok-Man Hong, PhD

This study will investigate the efficacy and safety of intrathecal morphine for the patients undergoing robot-assisted prostatectomy

Prostatectomy is the treatment of choice for prostate cancer. The robot-assisted prostatectomy is becoming the most popular surgical method for prostate cancer. The small incision after robot-assisted prostatectomy is thought to reduce the postoperative pain. There is few investigations for the strategy to reduce the postoperative pain of robot-assisted prostatectomy.

The intrathecal morphine injection is known to reduce postoperative pain for surgeries like hepatectomy, myomectomy and open prostatectomy. This method, however, is not yet studied for the robot-assisted prostatectomy. This study will investigate the efficacy and safety of intrathecal morphine for the patients undergoing robot-assisted prostatectomy.

Intrathecal Morphine in Robot-assisted Prostatectomy

The Efficacy of Intrathecal Morphine in Patients Undergoing Robot-assisted Prostatectomy

The doctor blinded to the investigation will visit patients. The pain will be assessed at rest and at coughing using visual analogue scale.

The total amount of opioids (IV morphine) used for 24 hours after surgery will be recorded and compared.

The total amount of intraoperative opioids (IV remifentanil) will be recorded and compared.

Any side effects of opioids including nausea, vomiting, dizziness, sedation, headache, pruritus and respiratory depression will be recorded.

Seoul National University Hospital

Associate professor

Symptoms and General Pathology

Rare Diseases

Carcinoma

Carcinoma, Renal Cell

Pain

Adenocarcinoma

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Kidney Neoplasms

Urologic Neoplasms

Female Urogenital Diseases

Pregnancy Complications

Female Urogenital Diseases and Pregnancy Complications

Kidney Diseases

Urologic Diseases

Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma

Adjuvants, Anesthesia

Meperidine

The postoperative pain management includes both the intrathecal morphine injection and the intravenous patient-controlled analgesia. Demerol on demand will be injected intravenously.

The postoperative pain management includes only the intravenous patient-controlled analgesia. Demerol on demand will be injected intravenously.

Demerol 25 mg intravenously when pain scores more than 5.

Demerol on demand

To evaluate the efficacy and the safety of the intrathecal morphine injection in the open nephrectomy.

The open nephrectomy is the treatment of choice for live donor kidney transplantation and renal cell carcinoma. The incision for the nephrectomy causes severe postoperative pain. A single dose of intrathecal morphine(ITM) has been used for the postoperative pain of prostatectomy, transurethral resection of the prostate and hepatectomy. The effect of ITM for open nephrectomy has not been studied. Therefore, this prospective, randomized study will evaluate the efficacy and safety of a single 50 mcg dose of ITM added to intravenous patient controlled analgesia(IV-PCA), comparing to IV-PCA alone.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Intrathecal Morphine in Robot-assisted Prostatectomy	NCT01991275	Prostatic Neopl...	The intravenous... The intrathecal...	19 Years - 80 Years	Seoul National University Hospital
The Intrathecal Morphine for Nephrectomy	NCT01997788	Renal Cell Carc...	The intrathecal... The intravenous... Demerol on dema...	18 Years - 80 Years	Seoul National University Hospital

Spots Global Cancer Trial Database for the intrathecal morphine injection