Neoplasms

Digestive System Diseases

Gland and Hormone Related Diseases

All Conditions

Behaviors and Mental Disorders

Infections

Symptoms and General Pathology

Rare Diseases

Pancreatic Neoplasms

Suicide

Adenoviridae Infections

Communicable Diseases

Self-Injurious Behavior

Behavioral Symptoms

Virus Diseases

DNA Virus Infections

Gastrointestinal Neoplasms

Digestive System Neoplasms

Endocrine Gland Neoplasms

Gastrointestinal Diseases

Pancreatic Diseases

Endocrine System Diseases

Pancreatic Cancer

Patients who were treated with Theragene®,Ad5-yCD/mutTKSR39rep-ADP and radiation therapy

Theragene®,Ad5-yCD/ mutTKSR39rep-ADP with radiation therapy

Theragene arm

Jin-Hyeok Hwang, MD PhD

Replication-competent Adenovirus-mediated Double Suicide Gene Therapy (Theragene®,Ad5-yCD/mutTKSR39rep-ADP) showed safety and anti-cancer effect in patients with pancreatic cancer in phase I study.

From the experience of phase I study, the safety and efficacy of combination with standard chemotherapy and radiation therapy with Theragene treatment will be assessed in this study.

Phase IIa study of Replication-competent Adenovirus-mediated Double Suicide Gene Therapy (Theragene®,Ad5-yCD/mutTKSR39rep-ADP) with radiation therapy

An Exploratory Trial to Evaluate Efficacy and Safety for Combination Treatment of Adenovirus Double Suicide Gene Therapy

A Single Arm, Open, Exploratory Clinical Trial to Evaluate Efficacy and Safety for Combination Treatment of Replication Competent Adenovirus Double Suicide Gene Therapy(Theragene®,Ad5-yCD/mutTKSR39rep-ADP) and Radiation Therapy in Patients

the proportion of patients with advanced or metastatic cancer who have achieved complete response or partial response

the proportion of patients with advanced or metastatic cancer who have achieved complete response, partial response or stable disease

change of tumor marker in the process of assigned treatment

median time from beginning of treatment to death

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
An Exploratory Trial to Evaluate Efficacy and Safety for Combination Treatment of Adenovirus Double Suicide Gene Therapy	NCT04739046	Pancreas Cancer	Theragene arm	19 Years - 75 Years	Seoul National University Bundang Hospital
An Exploratory Trial to Evaluate Efficacy and Safety for Combination Treatment of Adenovirus Double Suicide Gene Therapy	NCT04739046	Pancreas Cancer	Theragene arm	19 Years - 75 Years	Seoul National University Bundang Hospital

Spots Global Cancer Trial Database for theragene arm