Blood and Lymph Conditions

All Conditions

Immune System Diseases

Lymphadenopathy

Sarcoidosis

Lymphadenitis

Lymphatic Diseases

Thoracic endosonography, either endobronchial or esophageal ultrasound controlled needle aspiration, is a minimally invasive diagnostic technique.

Thoracic endosonography is a minimal invasive diagnostic intervention

Thoracic endosonography

Christophe A Dooms, MD, PhD

Vincent Ninane, MD, PhD

Patients are often referred for E(B)US examination and sampling of enlarged mediastinal and/or hilar lymph nodes that are not visible on a standard chest X-ray but are discovered by accident on CT scan performed outside the context of lung cancer or extrathoracic malignancies. Since CT scan is largely used and E(B)US is a minimally invasive technique, these cases are explored more frequently but so far nothing is known, however, on the prevalence of abnormal findings in EBUS sampling in this particular population and on the clinical implications (mainly therapeutical implications) of E(B)US findings.

The primary aim is to assess the nature and prevalence of abnormal findings in samplings obtained during E(B)US-NA in the non-cancer patient with CT enlarged mediastinal/hilar lymph nodes that are not visible on chest X-ray. As secondary aims, the clinical implications of E(B)US-NA findings will be assessed, in particular the number of cases where a specific treatment is initiated.

Linear Endosonography for the Assessment of Sarcoidosis Stage O

CT Enlarged Mediastinal/Hilar Lymph Nodes Not Visible on Chest X-ray in the Non Cancer Patient : Diagnosis and Clinical Implications Using Endobronchial or Esophageal Ultrasound Controlled Needle Aspiration E(B)US-NA

The primary aim is to assess the nature and prevalence of abnormal findings in samplings obtained during E(B)US-NA in the non-cancer patient with CT enlarged mediastinal/hilar lymph nodes that are not visible on chest X-ray.

As secondary aims, the clinical implications of E(B)US-NA findings will be assessed, in particular the number of cases where a specific treatment is initiated.

Universitaire Ziekenhuizen KU Leuven

Neoplasms

Respiratory Tract (Lung and Bronchial) Diseases

Lung Neoplasms

Carcinoma, Non-Small-Cell Lung

Respiratory Tract Neoplasms

Thoracic Neoplasms

Lung Diseases

Respiratory Tract Diseases

Endobronchial-ultrasound controlled transbronchial needle aspiration (EBUS-TBNA) in combination with a transoesophageal-ultrasound controlled needle aspiration of mediastinal lymph nodes

Christophe Dooms

Kurt Tournoy

This is a prospective non-randomized multicenter clinical trial performing endobronchial and esophageal ultrasound for mediastinal lymph node staging of operable and resectable cT1-T2-selectedT3 cN1 cM0 NSCLC.

Provided no mediastinal lymph node metastases are proven by echoendoscopy, all patients will subsequently undergo surgical staging. Patients without tissue proof of mediastinal nodal disease at surgical staging will undergo a thoracotomy with systematic lymph node dissection. Provided mediastinal lymph node metastases are proven by echoendoscopy, the patient goes off study protocol and can further be assessed/treated according to local clinical practice.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Linear Endosonography for the Assessment of Sarcoidosis Stage O	NCT01383226	Lymphadenitis	Thoracic endoso...	18 Years -	Universitaire Ziekenhuizen KU Leuven
Assessment of Invasive Mediastinal Staging in cN1 Lung Cancer.	NCT01456429	Non-small Cell ...	Thoracic endoso...	18 Years -	Universitaire Ziekenhuizen KU Leuven
Assessment of Invasive Mediastinal Staging in cN1 Lung Cancer.	NCT01456429	Non-small Cell ...	Thoracic endoso...	18 Years -	Universitaire Ziekenhuizen KU Leuven

Spots Global Cancer Trial Database for thoracic endosonography