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Thymopentin

Adjuvants, Immunologic

Immunologic Factors

subcutaneously or intramuscular inject at the dosage of 10 mg every second day (twice a week) for consecutive 3 months.

S J Qiu, MD

Jia Fan, MD

The purpose of this study is to evaluate the clinical efficacy of thymopentin on the prevention of the recurrence and metastasis of small HCC after resection.

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies in China, and approximately 90% of the patients with HCC are also infected with hepatitis B virus (HBV).Chronic HBV infections are a leading cause of liver cirrhosis and hepatocellular carcinoma. Surgical resection provides a potentially curative outcome for patients who are indicated to this procedure; however, survival is far from satisfactory because of the high recurrence rate, which is approximately 38-65% during the first 5 years， even for small HCC resection , it is still as high as 43.5%，and contributed to the major cause of mortality. Several approaches have been reported to decrease the recurrence rate after curative resection of HCC, such as postoperative transcatheter arterial chemoembolization (TACE) , chemotherapy , cyclic retinoic acid , and adoptive immunotherapy . However, these approaches are either controversial or require further evaluation , a substantial need for novel treatments is required urgently.

Tumor-induced immuno-suppression leads to an imbalance within the immune system, which closely related to the HCC recurrence and metastasis after resection, and an effective response is needed to eliminate residual tumor cells after removal of the major tumor tissue by surgery. Immunomodulatory peptides, like thymopentin (TP5), may act as immunomodulatory agents in cancer chemotherapy. TP5 comprises the amino acids (Arg-Lys-Asp-Val-Tyr) and represents residues 32-36 of the nuclear protein thymopoietin (TP) . A multitude of in vivo studies have shown efficacy of TP5 treatment in the therapy of various diseases including neoplastic, immune deficiency, autoimmune, and recurrent viral diseases etc. It rectifies imbalances in the immune system without observable side effects, even at very high doses. Furthermore, TP5 is able to significantly inhibit proliferation and induce apoptosis in some type of cancer lines.

Thus TP5 can not only act as an immunomodulatory factor in cancer chemotherapy or anti-HBV therapy, but also has potential as a chemotherapeutic agent in human cancer therapy

Study of Thymopentin in Patients After Curative Resection of Small Hepatocellular Carcinoma

Phase III Study of Thymopentin in Patients After Curative Resection of Small

Fudan University

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Study of Thymopentin in Patients After Curative Resection of Small Hepatocellular Carcinoma	NCT00460681	Hepatocellular ...	Thymopentin	18 Years - 75 Years	Fudan University
Study of Thymopentin in Patients After Curative Resection of Small Hepatocellular Carcinoma	NCT00460681	Hepatocellular ...	Thymopentin	18 Years - 75 Years	Fudan University
Study of Thymopentin in Patients After Curative Resection of Small Hepatocellular Carcinoma	NCT00460681	Hepatocellular ...	Thymopentin	18 Years - 75 Years	Fudan University
Study of Thymopentin in Patients After Curative Resection of Small Hepatocellular Carcinoma	NCT00460681	Hepatocellular ...	Thymopentin	18 Years - 75 Years	Fudan University

Spots Global Cancer Trial Database for thymopentin

Every month we try and update this database with for thymopentin cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Spots Global Cancer Trial Database for thymopentin

Every month we try and update this database with for thymopentin cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for thymopentin cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.