Infections

Skin and Connective Tissue Diseases

All Conditions

Musculoskeletal Diseases

Symptoms and General Pathology

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Warts

Foot Diseases

Communicable Diseases

Papillomavirus Infections

Virus Diseases

DNA Virus Infections

Skin Diseases

Skin Diseases, Viral

Tumor Virus Infections

Skin Diseases, Infectious

Anti-Infective Agents

Central Nervous System Depressants

All Drugs and Chemicals

Pharmaceutical Solutions

Dermatologic Agents

Anti-Inflammatory Agents

Antirheumatic Agents

Analgesics

Other Dietary Supplements

Ethanol

Salicylic Acid

Petrolatum

Salicylates

Clotrimazole

Miconazole

Antifungal Agents

Keratolytic Agents

Anti-Inflammatory Agents, Non-Steroidal

Analgesics, Non-Narcotic

Cyclooxygenase Inhibitors

Enzyme Inhibitors

Pyruvate

Patients will receive pyruvic acid solution 70% prepared by solving of pyruvic acid in water/ethanol solution. Patients will be advised to apply the solution twice daily for a period of four weeks. Application of petrolatum to the surrounding normal skin protects against the corrosive effect of the concentrated acid.

Patients will receive a combination of salicylic acid 16.7%, lactic acid 16.7%, and collodion 100%. Patients will be advised to apply the solution twice daily for a period of four weeks. Application of petrolatum to the surrounding normal skin protects against the corrosive effect of the concentrated acid.

Pyruvic acid

Fatima Assaf, M.D.

Plantar warts can be bothersome and painful requiring treatment. The investigators will compare the efficacy of pyruvic acid and salicylic acid in treating multiple plantar warts. Patients with multiple plantar warts will be randomized to receive either pyruvic acid 70% or compound salicylic acid solution (salicylic acid 16.7%, lactic acid 16.7%, and collodion 100%) applying topically twice a day for 4 weeks. Patients will be visited every 2 weeks for one month after starting treatment and then every one month for up to 3 months. The number and size of warts will be evaluated.

Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts

Comparison of 70% Pyruvic Acid Solution and Duofilm Solution in Treatment of Plantar Wart

Patients will be visited every two weeks for one month and then every month for up to 3 months by a dermatologist. On each visit, warts will be inspected to determine the number of warts. Any wart totally non-detectable by inspection and touch will be considered as healed.

Patients will be visited every two weeks for one month and then every month for up to 3 months by a dermatologist. On each visit, warts will be inspected to determine the size of warts. The size of the warts will be calculated as the mean size of all the warts.

Isfahan University of Medical Sciences

Neoplasms

Blood and Lymph Conditions

Immune System Diseases

Rare Diseases

Lymphoma

Lymphoma, T-Cell

Lymphoma, T-Cell, Peripheral

Mycoses

Mycosis Fungoides

Lymphoma, T-Cell, Cutaneous

Neoplasms by Histologic Type

Lymphoproliferative Disorders

Lymphatic Diseases

Immunoproliferative Disorders

Lymphoma, Non-Hodgkin

Bacterial Infections

Bacterial Infections and Mycoses

Lymphosarcoma

Peripheral T-cell Lymphoma

Cutaneous T-cell Lymphoma

Antineoplastic Agents

Anti-Allergic Agents

Imiquimod

Fluocinonide

Immunomodulating Agents

Immunologic Factors

Adjuvants, Immunologic

Interferons

Glucocorticoids

Hormones

Hormone Antagonists

Fluocinonide (Vanos) cream 0.1% will be applied as currently approved by the FDA for treatment of corticosteroid responsive disorders of the skin. Treatment will continue for 4 months with a follow up at 6 and 12 months.

3.75% Imiquimod (Zyclara) Cream will be used as currently labeled by the FDA for treatment of actinic keratoses. Treatment will continue for 4 months with follow up at 6 and 12 months.

CTCL specific assessments to measure response in lesions will be done at each visit. Therapy initiates at day 1 followed by a visit at day 15. Visits will then be once a month for four months with a follow up at 6 and 12 months.

3.75% Imiquimod Cream

0.1% Fluocinonide Cream

Brian Poligone, M.D. Ph.D.

This study is being conducted by Brian Poligone, MD PhD. The purpose of this study is to determine safety, effectiveness, and tolerability of two topical therapies, imiquimod and fluocinonide, for patients with early stage Cutaneous T-cell Lymphoma (CTCL).

The purpose of the study is to compare the safety, effectiveness, and tolerability of two topical therapies, imiquimod and fluocinonide, for patients with early stage CTCL.

Effectiveness of Imiquimod Topical Cream in Early Stage Cutaneous T-cell Lymphoma

Feasibility Study to Determine Effectiveness of 3.75% Topical Imiquimod Cream and Topical Vanos (Fluocinonide) Cream 0.1% in the Treatment of Early Stage Cutaneous T-cell Lymphoma

Treatment phase will last 4 months with follow up at 6 and 12 months after initiation of therapy

Patients will be treated for 4 months and response rate assessed at 6 and 24 months after initiation of therapy.

We will record any adverse events that occur during the course of the study.

Using left over tissue from biopsies done at baseline, two weeks after initiation of therapy, and optional one done at week16. We are interested in making our tissue bank.

Bausch Health Americas, Inc.

Rochester Skin Lymphoma Medical Group, PLLC

Rochester General Hospital

Scientist II

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts	NCT02151630	Plantar Wart	Pyruvic acid Salicylic Acid	12 Years -	Isfahan University of Medical Sciences
Pyruvic Acid Versus Salicylic Acid Preparation in Treatment of Plantar Warts	NCT02151630	Plantar Wart	Pyruvic acid Salicylic Acid	12 Years -	Isfahan University of Medical Sciences
Effectiveness of Imiquimod Topical Cream in Early Stage Cutaneous T-cell Lymphoma	NCT02301494	Mycosis Fungoid...	3.75% Imiquimod... 0.1% Fluocinoni...	18 Years -	Rochester General Hospital

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