Neoplasms

Urinary Tract, Sexual Organs, and Pregnancy Conditions

Gland and Hormone Related Diseases

All Conditions

Symptoms and General Pathology

Rare Diseases

Ovarian Neoplasms

Cysts

Ovarian Cysts

Ovarian Cancer

All girls who presented with adnexal mass from 0-21 years old (inclusive).

Subjects will be identified from review of clinical records.

Girl aged 21 or below who attended the NTEC cluster from 1990-2021 with available medical records.

No intervention

KAREN NG, PI

KATHERINE LEE, Investigator

KAREN NG

KATHERINE LEE

To review the characteristic, presentation and outcome of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

Background, current evidence and key references:

In paediatric and adolescent girls, preservation of the ovaries for those suffering from ovarian masses requiring surgery is important to maximize future fertility. However, when one faces an ovarian mass in a girl, on one hand, there is potential fertility compromise in those who had extensive ovarian surgery, on the other hand there is a small but non-negligible potential malignancy risk. There are distinct differences in pathologies and imaging findings in girls compared to adults. There arises the question on the most suitable way to triage children for the suitable management, be it conservative, ovarian preserving or more radical surgery.

There have been different diagnostic tools developed to aid the evaluation of adnexal masses in women with only limited evidence on the usage of these tools when being applied to the paediatric and adolescent age group. Attempts have been made in creating treatment guidelines for children, however no prospective randomized trials exist in this area. Therefore, it is important to identify and develop the most suitable triage algorithm for this group of patients.

Aim of study:

In this study, we aim to review the presentation, participant characteristics, imaging findings and histopathological findings, and validate the applicability of the various diagnostic tools in the paediatric and adolescent population to hopefully develop a management algorithm to improve the ovarian preservation rate without jeopardizing the potential malignancy risk in girls with adnexal masses.

Aim to look at whether adult scoring systems for adnexal mass can be applied to the paediatric and adolescent population to differentiate between benign and malignant adnexal masses.

Hypothesis:

The current diagnostic algorithms available for adults are applicable to the paediatric and adolescent population.

Outcome measure:

Participant characteristics, imaging findings, biochemical markers, operative record and histopathological findings, post-operative complications, post-operative menstrual symptoms, and any subsequent reproductive outcome.

Methods of Data Analysis:

The presentation, characteristics, imaging prior to surgery, surgical approaches, histopathological diagnosis and outcome of participant who presented with adnexal masses will be reviewed. The findings according to the data obtained from the review of medical records will be compared to the pre-existing rules and management algorithm for adults. The scoring systems or algorithms will then be validated with histopathological findings or participant outcome to assess applicability in our study population.

SPSS statistical program (SPSS Inc. version 21; IBM Corp., Armonk, NY, USA) was used to analyse the data collected. Normally distributed data was described using means (SD), whereas non-normally distributed data were described using medians (range).

A probability value of \<0.05 was considered statistically significant.

All girls who presented with adnexal mass from 0-21 years old (inclusive)

Retrospective Review on PAEDIATRIC and ADOLESCENT ADNEXAL MASSES

To review the characteristic of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

To review the imaging findings of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

To review the biochemical markers of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

To review the operative record of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

To review the histopathological findings of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

To review the post-operative complications of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

To review the post-operative menstrual symptoms of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

To review the subsequent reproductive outcome of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

Chinese University of Hong Kong

Assistant Professor

Pathological Conditions, Anatomical

Jacqueline Searcy

Erin Rowell, MD

A child is eligible to participate in this study because she is having surgery on her ovary. The investigators may obtain a sample of any discarded tissue from the surgery for an ovarian tissue library. This study is being conducted to understand how common ovarian conditions effect the number and quality of ovarian follicles and the reproductive potential of the ovary.

The investigators intend to enroll 100 girls and women in this study who are undergoing surgery involving the ovary. This may include patients with different conditions for comparison, such as ovarian cysts or masses and ovarian torsion. For each patient, the investigators will obtain the discarded tissue from the operating room after the affected ovarian tissue is resected. The tissue sample will only be taken for the tissue library from ovarian tissue that would otherwise be discarded.

No additional tissue will be collected other than that which is already removed as part of the ovarian procedure. No additional surgery or other procedures will be performed for the purposes of this study. The tissue will be assigned a study ID number and the age, gender and diagnosis of the child will be entered on the tissue library log and maintained for the duration of the study.

Pediatric Ovarian Tissue Banking - Operative Specimens From Females 0-18 Years of Age

The primary purpose of this study is analyzing the histologically ovarian tissue obtained surgically due to different ovarian pathologies. The tissue will be stained and follicles of varying stages will be counted and compared for different patient ages and ovarian pathologies. The extra-cellular matrix will also be stained and compared between different patient ages and ovarian pathologies.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Retrospective Review on PAEDIATRIC and ADOLESCENT ADNEXAL MASSES	NCT05461872	Adnexal Mass	No intervention	1 Day - 21 Years	Chinese University of Hong Kong
Retrospective Review on PAEDIATRIC and ADOLESCENT ADNEXAL MASSES	NCT05461872	Adnexal Mass	No intervention	1 Day - 21 Years	Chinese University of Hong Kong
Pediatric Ovarian Tissue Banking - Operative Specimens From Females 0-18 Years of Age	NCT04118712	Benign Cysts Ov... Cystectomy Torsion Malignant Cysts...		- 18 Years	Ann & Robert H Lurie Children's Hospital of Chicago

Spots Global Cancer Trial Database for torsion

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Spots Global Cancer Trial Database for torsion

Every month we try and update this database with for torsion cancer trials from around the world to help patients and their families find trials that might be right for them. We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

Every month we try and update this database with for torsion cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.