Neoplasms

Digestive System Diseases

Gland and Hormone Related Diseases

All Conditions

Nutritional and Metabolic Diseases

Rare Diseases

Pancreatic Neoplasms

Malnutrition

Pancreatic Cancer

Patients scheduled for major pancreatic surgery will be screened for malnutrition by five screening scores chosen depending on their clinical applicability. After surgery, it will be evaluated which score predicts the best complications.

Patients scheduled for major pancreatic surgery (pancreaticoduodenectomy, distal resection, total resection) will be screened for malnutrition by the following screening scores: Nutritional Risk Screening Score 2002; Subjective Global Assessment; Malnutrition Universal Screening Tool; Mini Nutritional Assessment and Short Nutritional Assessment Questionnaire.

The postoperative outcome will be recorded, and the predictive value of each score will be calculated.

Evaluation of Nutritional Scores as Predictive Factors of Postoperative Outcome After Pancreatic Surgery

Five nutritional questionnaires are administered to each patient to assess their nutritional status and then evaluate if there is a correlation between them and the postoperative outcomes.

Association of each score with postoperative outcomes depending on certain patient's characteristics:age,type of disease,operation technique (open surgery versus laparoscopy)

Universita di Verona

MD, PhD, Prof.

Nervous System Diseases

Adenoma

Pituitary Diseases

Pituitary Neoplasms

Neoplasms, Glandular and Epithelial

Neoplasms by Histologic Type

Hypothalamic Diseases

Brain Diseases

Central Nervous System Diseases

Endocrine System Diseases

Endocrine Gland Neoplasms

Hypothalamic Neoplasms

Supratentorial Neoplasms

Brain Neoplasms

Central Nervous System Neoplasms

Nervous System Neoplasms

the tumor abuting or displacing the hypothalamus in the preoperative MR images

hypothalamic involvement (the hypothalamus is no longer identifiable) in the preoperative MR images

Total resection of HIPA in a single surgery

Total resection

HIPA was resected subtotally at first time, and the tumor remnant was removed at a later date

Staged resection

HIPA was resected subtotally at first time, and the tumor remnant was controled by the stereotactic radiation therapy

Subtotal resection followed by stereotactic radiation therapy

Tao Huang, PhD, MD

Prospective and randomized evaluate efficiency and safety of different treatment strategies for hypothalamus-invading pituitary adenomas (HIPA)

There are various treatment strategies for hypothalamus-invading pituitary adenomas (HIPA), such as total resection (TR), subtotal resection with radiosurgery (STR+RS), etc. However,the optimal treatment of HIPA is still controversial. In this study, we want to evaluate the efficiency and safety of different treatment strategies in adults with HIPA.

Efficiency and Safety of Different Treatment Strategies in Adults With Pituitary Adenomas With Hypothalamic Involvement

EQ-5D will be evaluated before the first surgery and after the first surgery in 2 years

EQ-5D will be evaluated before the second intervention and after the second intervention in 3 months

Visual Acuity statue will be evaluated using Snellen's chart before the first surgery and after the first surgery in 2 years

Visual Field statue will be evaluated using a Humphrey visual field analyser before the first surgery and after the first surgery in 2 years

Whether the Hormone Replacement Therapy was used (Yes or No) before the first surgery and after the first surgery in 2 years

Volumetric analysis of tumor volume before the first surgery, intraoperatively and 3 months and 2 years after the first surgery will be performed. In addition, Tumor volume will be evaluated before the second intervention and intraoperatively. Gross total resection is defined as no tumor present in gadolinium enhanced T1 sequences.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Evaluation of Nutritional Scores as Predictive Factors of Postoperative Outcome After Pancreatic Surgery	NCT05608538	Pancreatic and ...		18 Years -	Universita di Verona
Evaluation of Nutritional Scores as Predictive Factors of Postoperative Outcome After Pancreatic Surgery	NCT05608538	Pancreatic and ...		18 Years -	Universita di Verona
Efficiency and Safety of Different Treatment Strategies in Adults With Pituitary Adenomas With Hypothalamic Involvement	NCT04863456	Pituitary Adeno...	Total resection Staged resectio... Subtotal resect...	18 Years -	Wuhan Union Hospital, China
Evaluation of Nutritional Scores as Predictive Factors of Postoperative Outcome After Pancreatic Surgery	NCT05608538	Pancreatic and ...		18 Years -	Universita di Verona

Spots Global Cancer Trial Database for total resection