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Women that underwent laparoscopic myomectomy with subsequent power morcellation of the surgical specimens.

Women that underwent laparoscopic myomectomy with subsequent transvaginal extraction of the surgical specimens.

Power morcellation of surgical specimens after laparoscopic myomectomy.

Power morcellation

Transvaginal extraction of surgical specimens after laparoscopic myomectomy.

Transvaginal extraction

Antonio Simone Laganà, M.D.

Jvan Casarin, M.D.

Antonella Cromi, M.D., Ph.D.

Fabio Ghezzi, M.D.

Laparoscopic myomectomy represents the fertility-sparing gold standard approach for the management of subserosal and intramural uterine myomas: this technique allows faster recovery, less complications and improved surgical outcomes than laparotomy.

Despite these validated cornerstones of minimally invasive gynecology, the best approach for specimen retrieval is still debated. Among these approaches, surgical specimen retrieval after laparoscopic myomectomy could be performed by mini-laparotomy, by power morcellation using morcellator inserted through one of the ancillary trocars, or by transvaginal extraction through an endobag inserted at level of the posterior vaginal fornix (between the utero-sacral ligaments).

Unfortunately, mini-laparotomy has poor esthetic outcome and does not conform the current standards of minimally invasive surgery.

In addition, on 24 November 24 2014 the Food and Drug Administration updated a Safety Communication about Power Morcellation, warning against the use of laparoscopic power morcellators in the majority of women undergoing myomectomy or hysterectomy for treatment of fibroids, due to the risk of spreading an unsuspected uterine sarcoma within the abdomen and pelvis.

Considering this scenario, transvaginal extraction may represents a feasible approach for specimen retrieval. In this view, the current study aims to retrospectively compare surgical outcomes in women that underwent laparoscopic myomectomy with subsequent power morcellation (before the issuing of the abovementioned Safety Communication by the Food and Drug Administration) or transvaginal extraction (after the issuing of the abovementioned Safety Communication by the Food and Drug Administration) of the surgical specimens.

Laparoscopic Myomectomy With Morcellation or Transvaginal Extraction of Surgical Specimens.

Analysis of Surgical Outcomes in Women Undergoing Laparoscopic Myomectomy With Morcellation or Transvaginal Extraction of Surgical Specimens

Number of surgical complications (Clavien-Dindo Classification)

Duration of the surgery, expressed in minutes.

Blood loss during the surgery, expressed in milliliters (ml).

Duration of the hospitalization, expressed in days

Sexual function evaluated by Female Sexual Function Index questionnaire, investigating quantity and quality of sex \[scale total score minimum: 2 (worse outcome), maximum: 36 (best outcome)\]

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization	Link
Laparoscopic Myomectomy With Morcellation or Transvaginal Extraction of Surgical Specimens.	NCT03570879	Myoma;Uterus	Power morcellat... Transvaginal ex...	18 Years - 45 Years	Università degli Studi dell'Insubria
Laparoscopic Myomectomy With Morcellation or Transvaginal Extraction of Surgical Specimens.	NCT03570879	Myoma;Uterus	Power morcellat... Transvaginal ex...	18 Years - 45 Years	Università degli Studi dell'Insubria

Spots Global Cancer Trial Database for transvaginal extraction