Neoplasms

Symptoms and General Pathology

All Conditions

Neoplasm Metastasis

Neoplastic Processes

Diagnosis and dental treatment decision based on the criteria of the International Dental Federation (FDI).

Diagnosis and dental treatment decision according to CARS (Caries Associated with Restorations or Sealants) detection criteria.

Dental treatment of all dental needs present in adults related or not to the dental caries

Dental treatment

Maximiliano Cenci, PhD

This study will evaluate the effect of the International Dental Federation (FDI) criteria, compared to CARS (Caries Associated with Restorations or Sealants) detection criteria for evaluation of caries lesions around restorations in permanent teeth, in the outcomes related to oral health of adults, in a randomized clinical trial.

The study will consist of a randomised controlled trial of two parallel groups. One group will correspond to adults who will receive the diagnosis and indication of treatment according to the standard criteria, following the FDI criteria to classify the restorations marginal conditions and the presence of secondary caries (traditional group). And the other group will receive a diagnosis and treatment decision according to a minimal intervention approach, using as reference the detection criteria "Caries Associated with Restorations or Sealants" (CARS) - ICCMS (International Caries Classification and Management System) - conservative group). Patient evaluations will be performed yearly after 12 months. The primary outcome will be the number of surfaces restored with the need for new interventions. Secondary outcomes will be the impact of oral health on quality of life and cost-effectiveness.

Patients, clinical operators responsible for dental treatment, and the examiner who will assess the outcomes will be blind to the allocation group of the participants.

Caries Cognition and Identification in Adults

Caries Associated With Restorations or Sialants Cognition and Identification in Adults

The primary endpoint will be the number of surfaces restored requiring intervention, which is composed of the sum of components with different levels of severity: number of surfaces with new caries lesions, number of surfaces restored in need of repair, replacement, teeth with episodes of pain, teeth requiring endodontic treatment or extraction.

Effectiveness will be measured through the number of restored surfaces without intervention. The cost-effectiveness ratio will be expressed by the cost ratio of the FDI and CARS criteria and effectiveness (number of surfaces without the need for new interventions)

Federal University of Pelotas

Respiratory Tract (Lung and Bronchial) Diseases

Digestive System Diseases

Skin and Connective Tissue Diseases

Gland and Hormone Related Diseases

Blood and Lymph Conditions

Immune System Diseases

Nervous System Diseases

Rare Diseases

Behaviors and Mental Disorders

Lung Neoplasms

Stomach Neoplasms

Breast Neoplasms

Pancreatic Neoplasms

Lymphoma

Leukemia

Hematologic Neoplasms

Liver Neoplasms

Brain Neoplasms

Hematologic Diseases

Stomach Cancer

Pancreatic Cancer

Quality of Life

Lymphosarcoma

Biliary Tract Cancer

Brain Tumor, Childhood

Being referred to palliative care team before totally terminating their chemotherapy among adult participants.

Being referred to palliative care team when their last chemotherapy is ended among adult participants.

haven't been under the palliative care among adult participants

receiving the palliative care among pediatric participants

haven't received the palliative care among pediatric participants

Palliative Care Team provide a self-learning booklet, medical treatment and consultation about Advance Care Planning with chemotherapy by oncologist.

Early palliative care

Palliative Care Team provide a routine hospice care the same as other patients who doesn't participate this study after the chemotherapy is totally terminated

Routine hospice care

Young Ho Yun, MD-PhD

This study evaluates the change of quality of life, treatment decision and utilization of health care depending on the use of palliative care in advanced cancer patients by a prospective cohort study. Participants will be separated into different groups by their intentions for using palliative care. Every participant will carry out the questionnaire per 3 months. This cohort study will be ended a year after each participant enrolls. However, if the participant didn't survive during this study, the caregivers will be asked to fill out additional questionnaire after 3 months of the death.

Patients with advanced cancer report physical, emotional, social and economic problems that may be due to the cancer itself or its treatment. Previous studies have shown the benefit of early palliative care in oncology. However, many Korean patients tend to start palliative care late even in general hospital. Because of the late start of palliative care, the burden of medical expenses increases, on the other hand, the quality of life of terminally ill patients decrease.

In this study, the use of palliative care in advanced cancer patients will be evaluated by a prospective cohort study. The goals of this study are as follow:

First, the clinical, psycho-social, and cognitive factors affecting quality of life, decision making, and hospital utilization (palliative medical team medical treatment, hospice and medical care) of patients with advanced stage cancer will be investigated.

Second, this study will explore the effects of age-specific characteristics on quality of life and care.

Third, an index, which reflects age-specific characteristics and predicts the time and content of terminal care will be developed. Improvements on the quality of life and care of patients with advanced stage of cancer or metastatic cancer are expected to establish effective terminal care strategies through this study.

The patients' symptom and quality of life, choice of medical care, advance care planning and caregiver's burden of care will be evaluated every 3 months after confirming the willingness to use palliative care for cancer patients. 3 months after the death, a caregiver evaluation will be conducted and hospice use, medical expenses will be analyzed.

Prospective Cohort Study Depending on the Use of Palliative Care for Advanced Stage of Cancer Patients

Change of Quality of Life, Treatment Decision and Utilization of Health Care Depending on the Use of Palliative Care in Adult and Pediatric Patients With Advanced Stage of Cancer: a Prospective Cohort Study

to measure quality of life of adult patients developed by European Organisation for Research and Treatment of Cancer for Palliative Care

Patients survival and POLST(Physician Order for Life-Sustaining Treatment) documentation whether patients survive during the study period and write POLST documentation (Since POLST has no legal form in Korea, it is based on the format of each institution.)

"Patient Health Questionnaire-9 items" is used as assessment tool to measure depression of both patients and their caregivers by completing the questionnaire.

"Decision Conflict Scale" is used as assessment tool to measure a level of decision conflict in treatment of both patients and their caregivers by completing the questionnaire.

to measure the awareness of patients' status of prognosis in both patients and caregivers through two questions in the questionnaire. The first question is about the idea of the possibility of curing the patient's disease and asks patients thought about whether treatment is available for cure and prolong survival. The second question concerns the life expectancy of the patient.

to measure the perceived holistic health status(physical, mental, social, spiritual and general) in both patients and caregivers. caregivers (The patient is asked to answer the perceived health status into five stages.)

To measure Daily functional skills in elderly only in 65-year or order patients.

Direct medical cost will be collected through National Health Insurance Corporation and Indirect cost will be collected by caregiver's questionnaire. In addition, "EuroQoL 5 Dimensions 5 Levels (EQ-5D-5L)" tool will be included in the patient's questionnaire to measure the condition of patients at the same time.

In order to analyze the cost effectiveness, investigate the frequency of use of early palliative care programs, the use of life-sustaining treatment and hospicee, and the use of complementary and alternative medicine(CAM). CAM include Chinese medicine, aromatherapy, diet, and yoga, etc.

to assess the patient's awareness of advanced care planning and willingness to construct advanced care planning. The preference for palliative care is divided according to the life expectancy. Investigate the preference of palliative care in each case - if the life expectancy is within a year, within a few months, or within a few weeks.

To measure mental, social, spiritual quality of life of both patients and caregivers

"Pediatric Quality of Life Inventory(Peds QL)" will be used as assessment tool for QOL among pediatric patients.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Caries Cognition and Identification in Adults	NCT03108586	Secondary Carie...	Dental treatmen... Dental treatmen...	18 Years - 60 Years	Federal University of Pelotas
Prospective Cohort Study Depending on the Use of Palliative Care for Advanced Stage of Cancer Patients	NCT03222258	Stage IV Breast... Stage IV Pancre... Stage IV Colon ... Stage IV Gastri... Stage IV Lung C... Stage IV Liver ... Malignant Hemat... Biliary Cancer ... Pediatric Leuke... Pediatric Lymph... Pediatric Brain... Pediatric Solid...	Early palliativ... Routine hospice...	-	Seoul National University Hospital
Caries Cognition and Identification in Adults	NCT03108586	Secondary Carie...	Dental treatmen... Dental treatmen...	18 Years - 60 Years	Federal University of Pelotas
Prospective Cohort Study Depending on the Use of Palliative Care for Advanced Stage of Cancer Patients	NCT03222258	Stage IV Breast... Stage IV Pancre... Stage IV Colon ... Stage IV Gastri... Stage IV Lung C... Stage IV Liver ... Malignant Hemat... Biliary Cancer ... Pediatric Leuke... Pediatric Lymph... Pediatric Brain... Pediatric Solid...	Early palliativ... Routine hospice...	-	Seoul National University Hospital

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