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Hyperbaric oxygen (HBO2) - 100% oxygen at 2.4 atmospheres ATA for 90 minutes, Monday-Friday for 30 sessions (six weeks)

Trental (pentoxifylline), 400 milligrams three times a day in combination with Vitamin E, 400 international units orally twice daily for six months

Hyperbaric oxygen therapy at 2.4 atmospheres for 90 minutes for 30 sessions.

Hyperbaric Oxygen Therapy

Trental 400 mg three times daily, in combination with Vitamin E 400 IU twice daily

Trental Pill

Vitamin E 400 IU twice daily, in combination with Trental 400 mg three times daily

Enoch Huang, MD

This study aims to compare patients that receive hyperbaric oxygen or Trental and Vitamin E immediately after completion of radiation therapy to evaluate which treatment best reduces radiation fibrosis.

Acute Post-Radiation Hyperbaric Oxygen (HBO2) for Breast Cancer Patients Who Have Recently Completed Radiation Therapy

A Pilot Study Comparing Acute Post-Radiation Hyperbaric Oxygen (HBO2) Versus Trental and Vitamin E for Breast Cancer Patients Who Have Recently Completed Radiation Therapy as Part of Their Treatment Course

The Bakers Grade Assessment will be used to evaluate if lower incidence and severity of radiation fibrosis is observed in patients receiving post-operative hyperbaric oxygen treatment as compared to Trental and Vitamin E. The difference-from-baseline (DFB) score will be calculated to determine the incidence and severity of radiation fibrosis. Some patients may develop radiation fibrosis at a later time so the assessment will be done multiple throughout the three years to capture timing of fibrosis onset.

Short Form 20 is a survey that patients complete to indicate their overall quality of life. The SF-20 is weighted and summed to provide easily interpretable scales for physical and mental health.

Visual Analog Scale is a way for patients to assess their pain, on a scale of one to ten with ten being worst pain imaginable.

Study title	NCT ID	Conditions	Interventions	Eligibility	Organization
Acute Post-Radiation Hyperbaric Oxygen (HBO2) for Breast Cancer Patients Who Have Recently Completed Radiation Therapy	NCT03916068	Breast Cancer	Hyperbaric Oxyg... Trental Pill Vitamin E	18 Years -	Legacy Health System
Acute Post-Radiation Hyperbaric Oxygen (HBO2) for Breast Cancer Patients Who Have Recently Completed Radiation Therapy	NCT03916068	Breast Cancer	Hyperbaric Oxyg... Trental Pill Vitamin E	18 Years -	Legacy Health System
Acute Post-Radiation Hyperbaric Oxygen (HBO2) for Breast Cancer Patients Who Have Recently Completed Radiation Therapy	NCT03916068	Breast Cancer	Hyperbaric Oxyg... Trental Pill Vitamin E	18 Years -	Legacy Health System

Spots Global Cancer Trial Database for trental pill

Every month we try and update this database with for trental pill cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.