⭐️⭐️⭐️⭐️⭐️ "A total no brainer"

⭐️⭐️⭐️⭐️⭐️ "Love this, so easy."

Spots is the easy way to track your skin, mole and cancer changes.

Spots Global Cancer Trial Database for LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: LAL-AR-N-2005:Study Treatment for Children High Risk Acute Lymphoblastic Leukemia

Official Title: LAL-AR-N-2005: Study Treatment for Children High Risk Acute Lymphoblastic Leukemia

Study ID: NCT00526409

Study Description

Brief Summary: The study objective is to improve the global results obtained with LAL-AR-93 study, reaching an event free survival between 60-70%. Identify patients with bad prognosis, with minimal residual disease,who can benefit of allogenic bone marrow transplantation

Detailed Description: INDUCTION TREATMENT Systemic chemotherapy: PREDNISOLONE 60 mg/m2 /day, oral or i.v. x 21 days (1 to 22) 30 mg/m2 /day, oral or i.v. x 7 days (23 to 29) DAUNORUBICIN 30 mg/m2 , i.v. days 1,8,15 and 22 VINCRISTINE 1,5 mg/m2, i.v. days 1,8,15 and 22 L-ASPARAGINASE 10.000U/m2 i.m or i.v day 9,11,13,16,18,20,23,25 and 27 CYCLOPHOSPHAMIDE 500 mg/m2 i.v. days 1,2 and 29 Intrathecal chemotherapy: Days 1 and 22 according age: Age \<1 years 1-3 years \>3 years Methotrexate (MTX), mg 5 8 12 Ara-C, mg 16 20 30 Hydrocortisone,mg 10 10 20 Patients with \<10% blasts in M.O (day 14), and in complete response on week 5 or 6, and without MDR, start consolidation-intensification phase. Patients with \>10% blasts in MO day +14 or without CR after induction treatment, start consolidation-intensification phase and identifier a donor for a transplantation. CONSOLIDATION/INTENSIFICATION (C.I.) Two sequential cycles, alternating bloc I and bloc II BLOC I DEXAMETHASONE 10 mg/m2/d vo. days 1 to 5 and 5 mg/m2/d vo. days 6 and 7 VINCRISTINE 1.5 mg/m2/d, i.v. days 1 and 8 METHOTREXATE 5 g/m2 24 hours infusion + AF, day 1 ARA-C 1 g/m2/12 h, i.v., days 5 and 6 MERCAPTOPURINE 100 mg/m2/d, oral, days 1 to 5 CYCLOPHOSPHAMIDE 500 mg/m2 i.v. el day +8 INTRATHECAL CHEMOTHERAPY day 1. BLOC II DEXAMETHASONE 10 mg/m2/d, v o. days 1-5 and 5 mg/m2/d, v o. days 6 and 7 VINCRISTINE 1.5 mg/m2/d, days 1 and 8 METHOTREXATE 5 g/m2 24 h infusion + AF, day 1 ARA-C 1 g/m2 i.v/12 h, days 5 and 6 DAUNORUBICINE 30 mg/m2 i.v.day 1 L-ASPARAGINASE 20.000 u/m2/d, i.m. or i.v. day 7 INTRATHECAL CHEMOTHERAPY day 1 Patients with CR and MRD negative, follow chemotherapy. Patients with MDR \>0.01% after second cycle or considered previously MRD are candidates to allogenic transplantation after second cycle. REINDUCTION/INTENSIFICATION TREATMENT (R.I.) PREDNISOLONE 60 mg/m2/d, oral x 14 days (1-14) 30 mg/m2/d, oral x 7 days (15-22) VINCRISTINE 1.5 mg/m2, i.v. x 2 days 1 and 8 DAUNORUBICINE 30 mg/m2 i.v x 2 , days 1 and 8 CYCLOPHOSPHAMIDE 500 mg/m2 I.V. day 15 ----------------------------------------- METHOTREXATE 3 g/m2 /24 h infusion + AF day 29 MERCAPTOPURINE 50 mg/m2/d, oral, days 29-35 and 43-50 ARA-C 1 g/m2/12 h., i.v., days 43 and 44 INTRATHECAL CHEMOTHERAPY , days 1, 15, 29 and 43 MAINTENANACE TREATMENT (M1) Six cycles of: MERCAPTOPURINE 50 mg/m2/d, oral x 21 days (1-21) METHOTREXATE 20 mg/m2/d, i.m. /week x 3 (1,7,14) PREDNISOLONE 60 mg/m2/d, oral x 7 days (22-28) VINCRISTINE 1.5 mg/m2 i.v.day 22 ASPARAGINASE 20.000 u/m2 i.m. day 22 INTRATHECAL CHEMOTHERAPY day 22 MAINTENANCE TREATMENT (M2) Diary mercaptopurine and weekly methotrexate at previous doses, until complete 24 months.

Eligibility

Minimum Age:

Eligible Ages: CHILD

Sex: ALL

Healthy Volunteers: No

Locations

Hospital materno Infantil vall d'Hebrón, Barcelona, , Spain

Hospital Niño Jesús, Madrid, , Spain

Hospital Virgen de la Arrixaca, Murcia, , Spain

Hospital Infantil Carlos Haya, Málaga, , Spain

Contact Details

Name: Bastida Pilar, Dr

Affiliation: Hospital Universitari Materno-Infantil Vall d'Hebron

Role: STUDY_CHAIR

Name: Ribera Josep Mª, Dr

Affiliation: Germans Trias i Pujol Hospital

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

Logo

Take Control of Your Skin and Body Changes Today.

Try out Spots for free, set up only takes 2 mins.

spots app storespots app store

Join others from around the world: