Spots Global Cancer Trial Database for A Multiple Ascending Dose Study of MEDI7247 in Patients With Selected Relapsed/Refractory Hematological Malignancies
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Trial Identification
Brief Title: A Multiple Ascending Dose Study of MEDI7247 in Patients With Selected Relapsed/Refractory Hematological Malignancies
Official Title: A Phase 1 Multicenter, Open-label, Dose-escalation and Dose-expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Antitumor Activity of MEDI7247 in Patients With Selected Relapsed/Refractory Hematological Malignancies
Study ID: NCT03106428
Interventions
Study Description
Brief Summary: To assess safety and tolerability, describe the dose-limiting toxicities, determine the maximum tolerated dose (MTD) or the highest protocol-defined dose (maximum administered dose) in the absence of establishing the MTD, and a recommended dose for further evaluation of MEDI7247 in patients with selected hematological malignancies who have relapsed after, or are refractory to prior standard therapy, and for whom there is no standard salvage regimen available.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Los Angeles, California, United States
Research Site, Denver, Colorado, United States
Research Site, Atlanta, Georgia, United States
Research Site, Chicago, Illinois, United States
Research Site, Boston, Massachusetts, United States
Research Site, Saint Louis, Missouri, United States
Research Site, New York, New York, United States
Research Site, Greer, South Carolina, United States
Research Site, Nashville, Tennessee, United States
Research Site, San Antonio, Texas, United States
Research Site, Pierre Benite, , France
Research Site, Villejuif, , France
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Contact Details
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