Spots Global Cancer Trial Database for Studying Genes in Samples From Younger Patients With Adrenocortical Tumor

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Trial Identification

Brief Title: Studying Genes in Samples From Younger Patients With Adrenocortical Tumor

Official Title: Using New Approaches for Genomics Studies in Pediatric Adrenocortical Tumors: Whole Genome Sequencing; Deep Sequencing; miRNA; methDNA and SNP 6.0

Study ID: NCT01528956

Conditions

Adrenocortical Carcinoma

Interventions

DNA methylation analysis

RNA analysis

gene expression analysis

nucleic acid sequencing

polymorphism analysis

Study Description

Brief Summary: RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. PURPOSE: This research trial studies genes in samples from younger patients with adrenocortical tumor.

Detailed Description: OBJECTIVES: * To perform whole-genome sequencing, deep sequencing, micro RNA analysis, methylation status, copy number variation analysis, and single-nucleotide polymorphisms (SNPs) analysis in pediatric adrenocortical tumors and compare those results to those of the same patient's normal cells. OUTLINE: Archived tumor and blood samples are analyzed for whole-genome sequencing, deep sequencing, micro RNA , methylation status, copy variation, and single-nucleotide polymorphisms. Results are then compared with patients' normal cells.