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Spots Global Cancer Trial Database for Study of SQZ-eAPC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Study of SQZ-eAPC-HPV in Patients With HPV16+ Recurrent, Locally Advanced or Metastatic Solid Tumors

Official Title: A Phase 1/2, First-in-Human, Multicenter, Open-Label Study of SQZ-eAPC-HPV as Monotherapy and in Combination With Immune Checkpoint Inhibitor(s) in Patients With HPV16+ Recurrent, Locally Advanced, or Metastatic Solid Tumors

Study ID: NCT05357898

Study Description

Brief Summary: This is a Phase 1/2, first-in-human, open label, multicenter study to assess safety and tolerability, antitumor activity, and immunogenic and pharmacodynamic effects of SQZ-eAPC-HPV as monotherapy and in combination with pembrolizumab in patients with recurrent, locally advanced, or metastatic HPV16+ solid tumors. The study includes patients with head and neck, cervical, anal, vulvar, or penile cancer.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Honor Health Research Institute, Scottsdale, Arizona, United States

City of Hope Medical Center, Duarte, California, United States

University of Colorado Anschutz Cancer Pavillion, Aurora, Colorado, United States

Massachusetts General Hospital, Boston, Massachusetts, United States

Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, United States

University of Nebraska Medical Center, Omaha, Nebraska, United States

University of Cincinnati Medical Center, Cincinnati, Ohio, United States

Tennessee Oncology, PLLC, Nashville, Tennessee, United States

Vanderbilt University Medical Center, Nashville, Tennessee, United States

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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