Spots Global Cancer Trial Database for Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1
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Trial Identification
Brief Title: Phase 1/2 Study of MRTX849 in Patients With Cancer Having a KRAS G12C Mutation KRYSTAL-1
Official Title: A Phase 1/2 Multiple Expansion Cohort Trial of MRTX849 in Patients With Advanced Solid Tumors With KRAS G12C Mutation KRYSTAL-1
Study ID: NCT03785249
Study Description
Brief Summary: This study will evaluate the safety, tolerability, drug levels, molecular effects, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors that have a KRAS G12C mutation.
Detailed Description: This study will evaluate the safety, tolerability, pharmacokinetics, metabolites, pharmacodynamics, and clinical activity of MRTX849 (adagrasib) in patients with advanced solid tumors with a KRAS G12C mutation. MRTX849 (adagrasib) is an orally-available small molecule inhibitor of KRAS G12C.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Alabama at Birmingham, Birmingham, Alabama, United States
Alaska Oncology and Hematology, Anchorage, Alaska, United States
Mayo Clinic in Arizona, Phoenix, Arizona, United States
Arizona Oncology Associates, Tucson, Arizona, United States
Kaiser Permanente-Bellflower Medical Offices, Bellflower, California, United States
Beverly Hills Cancer Center, Beverly Hills, California, United States
City of Hope, Duarte, California, United States
St. Joseph Heritage Healthcare, Fullerton, California, United States
University of California San Diego Moores Cancer Center, La Jolla, California, United States
Cancer & Blood Specialty Clinic, Los Alamitos, California, United States
Valkyrie Clinical Trials, Los Angeles, California, United States
Hoag Memorial Hospital Presbyterian, Newport Beach, California, United States
University of California, Irvine, Orange, California, United States
California Cancer Associates for Research and Excellence, San Diego, California, United States
Ridley - Tree Cancer Center - Santa Barbara, Santa Barbara, California, United States
Kaiser Permanente, Vallejo, California, United States
Rocky Mountain Cancer Centers, Aurora, Colorado, United States
University of Colorado Hospital, Aurora, Colorado, United States
SCL Health - Saint Joseph Hospital Cancer Center, Denver, Colorado, United States
St. Mary's Hospital & Regional Medical Center - Research, Grand Junction, Colorado, United States
Yale Cancer Center, New Haven, Connecticut, United States
Medical Oncology Hematology Consultants, Newark, Delaware, United States
SCRI - Florida Cancer Specialists- South, Fort Myers, Florida, United States
Mayo Clinic in Florida, Jacksonville, Florida, United States
Mount Sinai Comprehensive Cancer Center, Miami Beach, Florida, United States
Miami Cancer Institute Baptist Health, Miami, Florida, United States
Florida Cancer Affiliates - Ocala, Ocala, Florida, United States
Mid Florida Hematology and Oncology Center, Orange City, Florida, United States
Woodlands Medical Specialists, Pensacola, Florida, United States
BRCR Medical Center, Plantation, Florida, United States
SCRI - Florida Cancer Specialists-North, Saint Petersburg, Florida, United States
SCRI - Florida Cancer Specialists- East, West Palm Beach, Florida, United States
University Cancer and Blood Center, Athens, Georgia, United States
Northwest Georgia Oncology Centers, PC, Marietta, Georgia, United States
Affiliated Oncologists - Millenium Medical Center, Chicago Ridge, Illinois, United States
Illinois Cancer Specialists - Niles, Niles, Illinois, United States
Memorial Hospital South Bend, South Bend, Indiana, United States
University of Iowa Hospital & Clinics, Iowa City, Iowa, United States
University of Kansas Medical Center, Westwood, Kansas, United States
University of Kentucky, Lexington, Kentucky, United States
SCRI - Hematology Oncology Clinic, Baton Rouge, Louisiana, United States
Main Health Cancer Center Biddeford, Biddeford, Maine, United States
Maryland Oncology Hematology-Columbia, Columbia, Maryland, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States
Henry Ford Medical Center, Detroit, Michigan, United States
Minnesota Oncology, Minneapolis, Minnesota, United States
University of Minnesota, Minneapolis, Minnesota, United States
Mayo Clinic in Minnesota, Rochester, Minnesota, United States
Metro-Minnesota Community Oncology Research Consortium, Saint Louis Park, Minnesota, United States
Central Care Cancer Center - Bolivar, Bolivar, Missouri, United States
Goldschmidt Cancer Center- Central Region Medical Center, Jefferson City, Missouri, United States
Frontier Cancer Center, Billings, Montana, United States
Nebraska Cancer Specialists, Omaha, Nebraska, United States
University of Nebraska Medical Center, Omaha, Nebraska, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States
New York Oncology Hematology - Albany Medical Center, Albany, New York, United States
Roswell Park, Buffalo, New York, United States
Perlmutter Cancer Center, New York, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
University of North Carolina, Chapel Hill, North Carolina, United States
FirstHealth Outpatient Cancer Center, Pinehurst, North Carolina, United States
The Christ Hospital Cancer Center, Cincinnati, Ohio, United States
University of Cincinnati Health Barrett Cancer Center, Cincinnati, Ohio, United States
Cleveland Clinic, Cleveland, Ohio, United States
OSU Medical Center, Columbus, Ohio, United States
SCRI - Mark H. Zangmeister Cancer Center, Columbus, Ohio, United States
Kettering Cancer Center, Kettering, Ohio, United States
Cancer Centers of Southwest Oklahoma - Leah M. Fitch Cancer Center, Lawton, Oklahoma, United States
Oklahoma Cancer Specialist & Research Institute, Tulsa, Oklahoma, United States
St. Charles Health System, Bend, Oregon, United States
Willamette Valley Cancer Institute and Research Center - Eugene, Eugene, Oregon, United States
Lehigh Valley Heath, Allentown, Pennsylvania, United States
Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States
Alliance Cancer Specialists, Media, Pennsylvania, United States
Charleston Oncology P.A., Charleston, South Carolina, United States
Medical University of South Carolina, Charleston, South Carolina, United States
Tennessee Oncology/The Sarah Cannon Research Institute, Nashville, Tennessee, United States
USOR - Texas Oncology - Austin Central, Austin, Texas, United States
Mary Crowley Cancer Research, Dallas, Texas, United States
Texas Oncology- DFW, Dallas, Texas, United States
Oncology Consultants - Texas Medical Center, Houston, Texas, United States
The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
Lumi Research, Kingwood, Texas, United States
Texas Oncology Midland, Midland, Texas, United States
South Texas Accelerated Research Therapeutics, San Antonio, Texas, United States
Texas Oncology, Sugar Land, Texas, United States
Texas Oncology, Tyler, Texas, United States
Texas Oncology Waco, Waco, Texas, United States
Virginia Cancer Specialists, Fairfax, Virginia, United States
Hematology Oncology Associates of Fredericksburg, Fredericksburg, Virginia, United States
Virginia Oncology Associates-Newport News, Newport News, Virginia, United States
Virginia Cancer Institute, Richmond, Virginia, United States
Seattle Cancer Care Alliance, Seattle, Washington, United States
USOR - Compass Oncology - Vancouver, Vancouver, Washington, United States
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States
PanOncology Trials, San Juan, , Puerto Rico
Contact Details
Name: Hirak Der-Torossian
Affiliation: Mirati Therapeutics
Role: STUDY_DIRECTOR
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