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Brief Title: Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal Cancer
Official Title: An Open-Label, Randomized Phase 2 Study of ABT-869 in Combination With mFOLFOX6 (Oxaliplatin, 5-Fluorouracil, and Folinic Acid) Versus Bevacizumab in Combination With mFOLFOX6 as Second-line Treatment of Subjects With Advanced Colorectal Cancer
Study ID: NCT00707889
Brief Summary: To determine the effect of ABT-869 plus mFOLFOX6 compared to bevacizumab plus mFOLFOX6 on disease progression in advanced colorectal cancer.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Site Reference ID/Investigator# 11341, Chapel Hill, North Carolina, United States
Site Reference ID/Investigator# 20801, Philadelphia, Pennsylvania, United States
Site Reference ID/Investigator# 8360, Nashville, Tennessee, United States
Site Reference ID/Investigator# 18581, Bedford Park, , Australia
Site Reference ID/Investigator# 23443, Herston, , Australia
Site Reference ID/Investigator# 18023, Bonheiden, , Belgium
Site Reference ID/Investigator# 23646, Brussels, , Belgium
Site Reference ID/Investigator# 18026, Leuven, , Belgium
Site Reference ID/Investigator# 18022, Roeselare, , Belgium
Site Reference ID/Investigator# 26662, Jau, , Brazil
Site Reference ID/Investigator# 24245, Porto Alegre, , Brazil
Site Reference ID/Investigator# 23265, Barrie, , Canada
Site Reference ID/Investigator# 21083, Edmonton, , Canada
Site Reference ID/Investigator# 22465, Ottawa, , Canada
Site Reference ID/Investigator# 22141, Nachod, , Czech Republic
Site Reference ID/Investigator# 22289, Heraklion, , Greece
Site Reference ID/Investigator# 22286, Thessaloniki, , Greece
Site Reference ID/Investigator# 22287, Thessaloniki, , Greece
Site Reference ID/Investigator# 18281, Seoul, , Korea, Republic of
Site Reference ID/Investigator# 18283, Seoul, , Korea, Republic of
Site Reference ID/Investigator# 18282, Seoul, , Korea, Republic of
Site Reference ID/Investigator# 20281, Wellington South, , New Zealand
Site Reference ID/Investigator# 20141, Olsztyn, , Poland
Site Reference ID/Investigator# 17946, Warsaw, , Poland
Site Reference ID/Investigator# 38284, Warsaw, , Poland
Site Reference ID/Investigator# 23908, Aveiro, , Portugal
Site Reference ID/Investigator# 22324, Coimbra, , Portugal
Site Reference ID/Investigator# 23724, Faro, , Portugal
Site Reference ID/Investigator# 23964, Lisbon, , Portugal
Site Reference ID/Investigator# 23303, Baia Mare, , Romania
Site Reference ID/Investigator# 23302, Brasov, , Romania
Site Reference ID/Investigator# 17962, Bucharest, , Romania
Site Reference ID/Investigator# 17964, Bucharest, , Romania
Site Reference ID/Investigator# 23304, Bucharest, , Romania
Site Reference ID/Investigator# 17961, Cluj Napoca, , Romania
Site Reference ID/Investigator# 23305, Craiova, , Romania
Site Reference ID/Investigator# 24422, Moscow, , Russian Federation
Site Reference ID/Investigator# 25063, Moscow, , Russian Federation
Site Reference ID/Investigator# 25065, Moscow, , Russian Federation
Site Reference ID/Investigator# 24423, Moscow, , Russian Federation
Site Reference ID/Investigator# 22809, A Coruna, , Spain
Site Reference ID/Investigator# 22807, Barcelona, , Spain
Site Reference ID/Investigator# 22804, Madrid, , Spain
Site Reference ID/Investigator# 22801, Madrid, , Spain
Site Reference ID/Investigator# 22803, Pamplona Navarra, , Spain
Site Reference ID/Investigator# 22800, Santander, , Spain
Name: Mark D. McKee, MD
Affiliation: AbbVie
Role: STUDY_DIRECTOR