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Brief Title: Strategies for Maintenance Therapies in Advanced Non Small Cell Lung Cancer
Official Title: Phase III Study Evaluating Two Strategies of Maintenance, One With Pemetrexed in Continuous Strategy and One According to the Response of Induction Chemotherapy, in Non Squamous Non Small Cell Lung Cancer of Advanced Stage
Study ID: NCT01631136
Brief Summary: In France, lung cancer is responsible for more than 30000 each year. Progress was made in treatment of lung cancer in the last five years due to targeted therapies and to strategical evolutions consisting in a best adjustment of treatments. Maintenance strategies is one of this strategical evolution. It is based on maintaining continuous therapeutical pression in order to preserve the therapeutical benefit obtained by the first line (induction chemotherapy). Several clinical trials showed that maintenance strategies increase the duration of controlled disease. There is two types of maintenance strategies: * Continuous maintenance : prolongation of the treatment initially associated with platin until progression * Switch maintenance : introduction of a new treatment after the end of induction chemotherapy The aim of this study is to compare two maintenance strategies * A continuous maintenance by pemetrexed * A switch maintenance or a continuous maintenance according to the response of induction chemotherapy.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Abbeville - CH, Abbeville, , France
Centre Hospitalier du Pays d'Aix, Aix-en-Provence, , France
Clinique Claude Bernard, Albi, , France
Annemasse - CH, Ambilly, , France
Angers - CHU, Angers, , France
Annecy - CH, Annecy, , France
Hôpital Privé d'Antony, Antony, , France
Argenteuil -CH, Argenteuil, , France
Aubenas - CH, Aubenas, , France
CH de la Côte Basque, Bayonne, , France
Beauvais - CH, Beauvais, , France
CHU Besancon - Pneumologie, Besancon, , France
Hôpital Ambroise Paré - Pneumologie, Boulogne, , France
Béziers - CH, Béziers, , France
Caen - Centre François Baclesse, Caen, , France
Caen - CHU Côte de Nacre, Caen, , France
Cahors - CH, Cahors, , France
CH de Cannes, Cannes, , France
Castelnau Le Lez - Clinique, Castelnau, , France
CH Chambery, Chambery, , France
Charleville-Mézières - CH, Charleville-Mézières, , France
Centre Hospitalier, Chauny, , France
CH, Cholet, , France
Hôpital Percy-Armées - Pneumologie, Clamart, , France
CHU, Clermont-Ferrand, , France
Colmar - CH, Colmar, , France
Creil - GHPSO, Creil, , France
CHI Créteil, Créteil, , France
CH de Dax, Dax, , France
Centre d'Oncologie du Parc, Dijon, , France
Centre Georges François Leclerc, Dijon, , France
Draguignan - CH, Draguignan, , France
Grenoble - CHU, Grenoble, , France
Saint Omer - CHI, Helfaut, , France
CH de Jonzac, Jonzac, , France
La Roche Sur Yon - CH, La Roche Sur Yon, , France
Le Mans - Centre Hospitalier, Le Mans, , France
CHU (Hôpital Calmette) - Pneumologie, Lille, , France
Lille - GHPSO, Lille, , France
Limoges - Hôpital du Cluzeau, Limoges, , France
CH de Longjumeau, Longjumeau, , France
Centre Léon Bérard, Lyon, , France
CH Saint Joseph Saint Luc, Lyon, , France
Hôpital de la Croix Rousse, Lyon, , France
Hôpital Louis Pradel, Lyon, , France
Lyon - Hôpital Jean Mermoz, Lyon, , France
CH de Macon, Macon, , France
Hôpital Nord - Oncologie Multidisciplinaire & Innovations Thérapeutiques, Marseille, , France
Maubeuge - Polyclinique du Parc, Maubeuge, , France
Meaux - CH, Meaux, , France
Mont de Marsan - CH, Mont de Marsan, , France
Montpellier - Clinique Clémentville, Montpellier, , France
Centre Hospitalier, Montélimar, , France
Mulhouse - CH, Mulhouse, , France
Nancy - polyclinique Gentilly, Nancy, , France
CHU Nancy, Nancy, , France
Nevers - CH, Nevers, , France
Nice - CAC, Nice, , France
Orléans - CH, Orléans, , France
Paris - Saint Louis, Paris, , France
Hopital Tenon - Pneumologie, Paris, , France
GH Paris Saint-Joseph, Paris, , France
HIA Val-de-Grâce, Paris, , France
Hôpital Bichat - Claude - Bernard, Paris, , France
Paris - Curie, Paris, , France
Pau - CH, Pau, , France
HCL - Lyon Sud (Pneumologie), Pierre Bénite, , France
CHU, Poitiers, , France
Pontoise - CH, Pontoise, , France
Quimper - CH, Quimper, , France
Reims - CHU, Reims, , France
Institut Jean Godinot, Reims, , France
Rennes - CHU, Rennes, , France
Roubaix - CH, Roubaix, , France
Saint Priest en Jarez - ICL, Saint Priest en Jarez, , France
Saint Quentin - CH, Saint Quentin, , France
Saint-Cloud - Centre René Huguenin, Saint-Cloud, , France
Salon de Provence - CH, Salon de Provence, , France
Sens - CH, Sens, , France
Strasbourg - NHC, Strasbourg, , France
Thonon les bains - CH, Thonon les bains, , France
Toulon - CHI, Toulon, , France
Toulon - HIA, Toulon, , France
Toulouse - CHU Larrey, Toulouse, , France
Tourcoing - CH, Tourcoing, , France
Tours - CHU, Tours, , France
Valenciennes - Clinique, Valenciennes, , France
Versailles - CH, Versailles, , France
CHI de la Haute-Saône - Pneumologie, Vesoul, , France
CH de Villefranche - Pneumologie, Villefranche, , France
Centre Hospitalier Intercommunal, Villeneuve-Saint-Georges, , France
Name: Maurice PEROL, MD
Affiliation: Centre Léon Bérard - Lyon
Role: PRINCIPAL_INVESTIGATOR
Name: Pierre-Jean SOUQUET, MD, PhD
Affiliation: Centre Hospitalier Lyon Sud
Role: PRINCIPAL_INVESTIGATOR