Spots Global Cancer Trial Database for A Study of ABBV-927 and ABBV-181, an Immunotherapy, in Participants With Advanced Solid Tumors
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Trial Identification
Brief Title: A Study of ABBV-927 and ABBV-181, an Immunotherapy, in Participants With Advanced Solid Tumors
Official Title: A Multicenter, Phase 1, Open-Label, Dose-Escalation Study of ABBV-927 and ABBV-181, an Immunotherapy, in Subjects With Advanced Solid Tumors
Study ID: NCT02988960
Conditions
Study Description
Brief Summary: This is a dose-escalation study designed to evaluate the safety, pharmacokinetics, and pharmacodynamics of ABBV-927, and to determine the maximum tolerated dose (MTD) or recommended Phase 2 dose (RPTD) for ABBV-927 when administered as monotherapy or as combination therapy with ABBV-181 in participants with advanced solid tumors.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
The Angeles Clinic and Researc /ID# 156324, Los Angeles, California, United States
The University of Chicago Medical Center /ID# 155264, Chicago, Illinois, United States
Massachusetts General Hospital /ID# 155267, Boston, Massachusetts, United States
Carolina BioOncology Institute /ID# 155265, Huntersville, North Carolina, United States
Tennessee Oncology-Nashville Centennial /ID# 158654, Nashville, Tennessee, United States
University of Texas MD Anderson Cancer Center /ID# 155263, Houston, Texas, United States
Virginia Cancer Specialists - Fairfax /ID# 155266, Fairfax, Virginia, United States
Peninsula Oncology Centre /ID# 164372, Frankston, Victoria, Australia
Austin Health /ID# 171189, Heidelberg, Victoria, Australia
Princess Margaret Cancer Centre /ID# 200819, Toronto, Ontario, Canada
Institut Bergonie /ID# 162665, Bordeaux, Gironde, France
Duplicate_Institut Regional du Cancer /ID# 163609, Montpellier CEDEX 5, Herault, France
Centre Leon Berard /ID# 162663, Lyon CEDEX 08, Rhone, France
Institut Gustave Roussy /ID# 162666, Villejuif Cedex, Val-de-Marne, France
National Cancer Center Hospital East /ID# 216870, Kashiwa-shi, Chiba, Japan
National Cancer Center Hospital /ID# 217758, Chuo-ku, Tokyo, Japan
Yonsei University Health System Severance Hospital /ID# 166292, Seoul, Seoul Teugbyeolsi, Korea, Republic of
Seoul National University Hospital /ID# 166291, Seoul, , Korea, Republic of
Hospital Universitario Puerta de Hierro, Majadahonda /ID# 200129, Majadahonda, Madrid, Spain
Hospital Universitario Fundacion Jimenez Diaz /ID# 200128, Madrid, , Spain
Hospital Universitario HM Sanchinarro /ID# 200127, Madrid, , Spain
Hospital Universitario y Politecnico La Fe /ID# 200975, Valencia, , Spain
Contact Details
Name: ABBVIE INC.
Affiliation: AbbVie
Role: STUDY_DIRECTOR
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