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Spots Global Cancer Trial Database for A Study Evaluating the Safety, Pharmacokinetics (PK), and Preliminary Efficacy of ABBV-399 in Participants With Advanced Solid Tumors

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Trial Identification

Brief Title: A Study Evaluating the Safety, Pharmacokinetics (PK), and Preliminary Efficacy of ABBV-399 in Participants With Advanced Solid Tumors

Official Title: A Multicenter, Phase 1/1b, Open-Label, Dose-Escalation Study of ABBV-399, an Antibody Drug Conjugate, in Subjects With Advanced Solid Tumors

Study ID: NCT02099058

Study Description

Brief Summary: This is a Phase 1/1b open-label study evaluating the safety, pharmacokinetics (PK), and preliminary efficacy of ABBV-399 as monotherapy and in combination with osimertinib, erlotinib, and nivolumab in participants with advanced solid tumors likely to express c-Met. Enrollment is closed for the monotherapy arms, Arm A, and Arm D.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Scottsdale Healthcare /ID# 123761, Scottsdale, Arizona, United States

City of Hope /ID# 153759, Duarte, California, United States

University of California, Los Angeles /ID# 148295, Los Angeles, California, United States

UC Irvine /ID# 165107, Orange, California, United States

University of California, Davis Comprehensive Cancer Center /ID# 129805, Sacramento, California, United States

Univ of Colorado Cancer Center /ID# 123759, Aurora, Colorado, United States

The University of Chicago Medical Center /ID# 136995, Chicago, Illinois, United States

Ingalls Memorial Hosp /ID# 165876, Harvey, Illinois, United States

Massachusetts General Hospital /ID# 129804, Boston, Massachusetts, United States

Dana-Farber Cancer Institute /ID# 168782, Boston, Massachusetts, United States

Henry Ford Health System /ID# 149857, Detroit, Michigan, United States

Herbert Herman Cancer Center /ID# 149858, Lansing, Michigan, United States

Washington University-School of Medicine /ID# 143798, Saint Louis, Missouri, United States

Summit Medical Group-Florham Park /ID# 217651, Florham Park, New Jersey, United States

Montefiore Medical Park at Eastchester /ID# 218445, Bronx, New York, United States

Northwell Health - Monter Cancer Center /ID# 218170, Lake Success, New York, United States

Duke Cancer Center /ID# 123763, Durham, North Carolina, United States

Tennessee Oncology, PLLC /ID# 129802, Nashville, Tennessee, United States

Mary Crowley Cancer Research /ID# 123760, Dallas, Texas, United States

University of Texas MD Anderson Cancer Center /ID# 154648, Houston, Texas, United States

Virginia Cancer Specialists - Fairfax /ID# 165708, Fairfax, Virginia, United States

Universitair Ziekenhuis Antwerpen /ID# 170118, Edegem, Antwerpen, Belgium

Tampere University Hospital /ID# 165065, Tampere, Pirkanmaa, Finland

AP-HM - Hopital de la Timone /ID# 151570, Marseille CEDEX 05, Bouches-du-Rhone, France

Institut Gustave Roussy /ID# 132747, Villejuif Cedex, Val-de-Marne, France

Duplicate_Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRCCS /ID# 164077, Meldola, Emilia-Romagna, Italy

National Cancer Center Hospital East /ID# 217570, Kashiwa-shi, Chiba, Japan

National Cancer Center Hospital /ID# 217571, Chuo-ku, Tokyo, Japan

The Catholic University of Korea, ST. Vincent's Hospital /ID# 233378, Suwon, Gyeonggido, Korea, Republic of

Yonsei University Health System Severance Hospital /ID# 217333, Seoul, Seoul Teugbyeolsi, Korea, Republic of

Asan Medical Center /ID# 217334, Seoul, , Korea, Republic of

Radboud Universitair Medisch Centrum /ID# 246908, Nijmegen, Gelderland, Netherlands

China Medical University Hospital /ID# 217494, Taichung, , Taiwan

National Cheng Kung University Hospital /ID# 167175, Tainan, , Taiwan

National Taiwan University Hospital /ID# 167173, Taipei City, , Taiwan

Taipei Veterans General Hosp /ID# 217392, Taipei, , Taiwan

Contact Details

Name: ABBVIE INC.

Affiliation: AbbVie

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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