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Spots Global Cancer Trial Database for osimertinib

Every month we try and update this database with for osimertinib cancer trials from around the world to help patients and their families find trials that might be right for them.
We offer this 100% free of charge and do not endorse any of the trials listed here, we hope it helps you or a loved one.

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Study titleNCT IDConditionsInterventionsEligibilityOrganizationLink
A Prospective Study of Pembrolizumab Combining Chemotherapy in Advanced NSCLC Patients With EGFR Exon 21 Point Mutation.NCT06142617
Non Small Cell ...
Immune Checkpoi...
EGFR Exon 21 Mu...
Pembrolizumab, ...
Osimertinib
18 Years - Peking Union Medical College Hospital
Study to Assess the Efficacy and Safety of Adjuvant Osimertinib in NSCLC With Uncommon EGFRmNCT05546866
Non-small Cell ...
Osimertinib
18 Years - 130 YearsAstraZeneca
Osimertinib (AZD9291) in First-line Locally Advanced or Metastatic NSCLC Patients With EGFR and EGFR T790MNCT02841579
Non-Small Cell ...
Osimertinib
18 Years - MedSIR
Combination of Osimertinib and Aspirin to Treat 1st Generation EGFR-TKI Resistance in NSCLCNCT03543683
Non-Small Cell ...
Non-small Cell ...
EGFR T790M
Osimertinib
Aspirin
18 Years - 75 YearsDaping Hospital and the Research Institute of Surgery of the Third Military Medical University
A Multi-Centre, Prospective, Non-Interventional Study to Intensively Monitor the Safety of Osimertinib in Clinical Practice Among Chinese NSCLC PatientsNCT03485326
Non-small Cell ...
- AstraZeneca
An Open-Label Phase 1/2 Study of Itacitinib in Combination With Osimertinib in Subjects With Non-Small Cell Lung CancerNCT02917993
Lung Cancer
Itacitinib
Osimertinib
18 Years - Incyte Corporation
Biologically Guided Radiation Therapy (BgRT) and Stereotactic Body Radiation Therapy (SBRT) With Osimertinib for the Treatment of Patients With Oligoprogressive EGFR Positive Non-small Cell Lung CarcinomaNCT06014827
Lung Non-Small ...
Stage IV Lung C...
Biospecimen Col...
Computed Tomogr...
Osimertinib
Positron Emissi...
Stereotactic Bo...
Survey Administ...
18 Years - City of Hope Medical Center
EMB-01 in Combination With Osimertinib in Patients With EGFR Mutant Lung CancerNCT05498389
Metastatic Lung...
Advanced Lung N...
Stage IV Lung C...
Stage IVA Lung ...
Stage IVB Lung ...
Stage III Lung ...
Stage IIIA Lung...
Stage IIIB Lung...
EGFR Mutation-R...
EMB-01
Osimertinib
18 Years - Shanghai EpimAb Biotherapeutics Co., Ltd.
JAB-3312 Based Combination Therapy in Adult Patients With Advanced Solid TumorsNCT04720976
Solid Tumor
NSCLC
JAB-3312
Binimetinib
Pembrolizumab
Sotorasib
Osimertinib
18 Years - Jacobio Pharmaceuticals Co., Ltd.
To Evaluate the Efficacy/Safety of Osimertinib Prior to CRT and Maintenance of it With Stage III, Unresectable NSCLC With EGFR MutationsNCT06194448
Lung Cancer
Osimertinib
Cisplatin or Ca...
Radiation
18 Years - 130 YearsAstraZeneca
A Randomised Phase II Trial of Osimertinib With or Without SRS for EGFR Mutated NSCLC With Brain MetastasesNCT03497767
Metastatic Non ...
Osimertinib
Stereotactic Ra...
18 Years - Trans Tasman Radiation Oncology Group
Combination of Osimertinib and Aspirin to Treat Osimertinib Resistance Non-small Cell Lung Cancer ( NSCLC)NCT03532698
Non-Small Cell ...
Non-small Cell ...
EGFR T790M
Aspirin
Osimertinib
18 Years - 75 YearsDaping Hospital and the Research Institute of Surgery of the Third Military Medical University
Study of Osimertinib in Patients With a Lung Cancer With Brain or Leptomeningeal Metastases With EGFR MutationNCT04233021
Non Small Cell ...
Leptomeningeal ...
Brain Metastase...
EGFR Activating...
Osimertinib
18 Years - Intergroupe Francophone de Cancerologie Thoracique
Afatinib Osimertinib Sequencing NISNCT03370770
Carcinoma, Non-...
Afatinib
Osimertinib
18 Years - Boehringer Ingelheim
Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung CancerNCT04181060
Advanced Lung N...
Metastatic Lung...
Recurrent Lung ...
Stage IIIB Lung...
Stage IV Lung C...
Bevacizumab
Biospecimen Col...
Computed Tomogr...
Echocardiograph...
Magnetic Resona...
Multigated Acqu...
Osimertinib
18 Years - National Cancer Institute (NCI)
Local Ablative Therapy for Treatment of Oligoprogressive, EGFR-Mutated, Non-Small Cell Lung Cancer After Treatment With OsimertinibNCT02759835
Lung Adenocarci...
Lung Neoplasms
osimertinib
Local Ablative ...
18 Years - National Institutes of Health Clinical Center (CC)
Aurora Kinase Inhibitor LY3295668 in Combination With Osimertinib for the Treatment of Advanced or Metastatic EGFR-Mutant Non-squamous Non-small Cell Lung CancerNCT05017025
Advanced Lung N...
Metastatic Lung...
Stage III Lung ...
Stage IIIA Lung...
Stage IIIB Lung...
Stage IIIC Lung...
Stage IV Lung C...
Stage IVA Lung ...
Stage IVB Lung ...
Aurora A Kinase...
Osimertinib
18 Years - M.D. Anderson Cancer Center
First in Human Study of AZD9592 in Solid TumorsNCT05647122
Advanced Solid ...
Carcinoma Non-s...
Head and Neck N...
Colorectal Neop...
AZD9592
Osimertinib
5-Fluorouracil ...
Leucovorin
Bevacizumab
18 Years - AstraZeneca
A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Advanced NSCLCNCT04959981
Advanced Non-sq...
ERAS-007
ERAS-601
Osimertinib
Sotorasib
18 Years - 99 YearsErasca, Inc.
Osimertinib With or Without Savolitinib as 1L in de Novo MET+, EGFR+ NSCLCNCT05163249
Carcinoma, Non-...
Osimertinib
Savolitinib
18 Years - Guangdong Association of Clinical Trials
SI-B001 Combined With Osimertinib Mesylate Tablets in the Treatment of Recurrent Metastatic Non-small Cell Lung Cancer.NCT05020769
Non-small Cell ...
SI-B001
Osimertinib
18 Years - Sichuan Baili Pharmaceutical Co., Ltd.
T-DM1 and Osimertinib Combination Treatment to Target HER2 Bypass Track Resistance in EGFR Mutation Positive NSCLCNCT03784599
Carcinoma, Non-...
Trastuzumab emt...
Osimertinib
18 Years - The Netherlands Cancer Institute
Osimertinib for NSCLC With Uncommon EGFR MutationsNCT05421936
Carcinoma, Non-...
Genes, erbB-1
Osimertinib
18 Years - 99 YearsSheba Medical Center
A Study to Investigate Safety and Efficacy of Osimertinib and Amivantamab in Participants With Non-small Cell Lung Cancer With Common Epidermal Growth Factor Receptor MutationsNCT05801029
Non-Small Cell ...
Osimertinib
Amivantamab
18 Years - 130 YearsAstraZeneca
A Molecular Profiling Study of Patients With EGFR Mutation-positive Locally Advanced or Metastatic NSCLC Treated With OsimertinibNCT03239340
EGFR Mutation P...
Osimertinib
18 Years - 130 YearsAstraZeneca
A Study to Investigate Safety and Efficacy of Osimertinib and Amivantamab in Participants With Non-small Cell Lung Cancer With Common Epidermal Growth Factor Receptor MutationsNCT05801029
Non-Small Cell ...
Osimertinib
Amivantamab
18 Years - 130 YearsAstraZeneca
A Study With BPI-1178 and Osimertinib in Advanced Non-small Cell Lung Cancer Patients With EGFR MutationsNCT06362980
NSCLC
BPI-1178
Osimertinib
18 Years - National Cancer Center, China
Osimertinib Plus Chemotherapy in Uncommon EGFRm NSCLCNCT05215951
Lung Cancer
osimertinib
18 Years - AstraZeneca
A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Advanced NSCLCNCT04959981
Advanced Non-sq...
ERAS-007
ERAS-601
Osimertinib
Sotorasib
18 Years - 99 YearsErasca, Inc.
Neurocognition in NSCLC Patients Treated With Osimertinib or Osimertinib + WBINCT04829019
Neurocognitive
Osimertinib and...
Osimertinib
18 Years - Sun Yat-sen University
Osimertinib and Bevacizumab as Treatment for EGFR-mutant Lung CancersNCT02803203
Non-small Cell ...
EGFR-mutant Lun...
osimertinib
Bevacizumab
19 Years - Memorial Sloan Kettering Cancer Center
Osimertinib Treatment on EGFR T790M Plasma Positive NSCLC Patients (APPLE)NCT02856893
NSCLC
Osimertinib
Gefitinib
18 Years - European Organisation for Research and Treatment of Cancer - EORTC
Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib.NCT06296745
Leptomeningeal ...
Pemetrexed
18 Years - 75 YearsGuangzhou Medical University
Osimertinib With or Without Bevacizumab for EGFR- Mutant Non-small Cell Lung Cancer With Leptomeningeal MetastasisNCT04148898
Leptomeningeal ...
Non-small Cell ...
EGFR Activating...
Osimertinib
Bevacizumab
18 Years - 80 YearsSecond Affiliated Hospital of Nanchang University
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Osimertinib (TAGRISSO) (ROSY-T)NCT05629234
Cancer
Osimertinib
18 Years - 99 YearsAstraZeneca
Telaglenastat Hydrochloride and Osimertinib in Treating Patients With EGFR-Mutated Stage IV Non-small Cell Lung CancerNCT03831932
Advanced Lung N...
Metastatic Lung...
Stage IV Lung C...
Biospecimen Col...
Computed Tomogr...
Magnetic Resona...
Osimertinib
Positron Emissi...
Telaglenastat H...
X-Ray Imaging
18 Years - National Cancer Institute (NCI)
Almonertinib Versus Osimertinib in the Patients With EGFR Mutations in Advanced NSCLC With Brain MetastasesNCT04870190
NSCLC
Almonertinib
Osimertinib
18 Years - Shanghai Chest Hospital
A Study Evaluating the Safety, Pharmacokinetics (PK), and Preliminary Efficacy of ABBV-399 in Participants With Advanced Solid TumorsNCT02099058
Advanced Solid ...
Osimertinib
Nivolumab
Telisotuzumab v...
Telisotuzumab v...
Erlotinib
18 Years - AbbVie
A Study to Learn About the Effectiveness of Cancer Medicines in Patients With Metastatic Non-small Cell Lung Cancer in Norway.NCT05834348
Non-Small Cell ...
lorlatinib
crizotinib
brigatinib
ceritinib
alectinib
atezolizumab
bevacizumab
paclitaxel
carboplatin
docetaxel
erlotinib
gefitinib
afatinib
dacomitinib
osimertinib
pembrolizumab
nivolumab
entrectinib
18 Years - 100 YearsPfizer
Study to Assess the Effect of Osimertinib (TAGRISSO™ ) on Blood Levels of Fexofenadine in Patients With EGFRm+ NSCLCNCT02908750
Non Small Cell ...
Fexofenadine ta...
Osimertininb ta...
18 Years - 130 YearsAstraZeneca
National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung CancerNCT02664935
Non-Small Cell ...
Carcinoma, Squa...
Adenocarcinoma
AZD4547
Vistusertib
Palbociclib
Crizotinib
Selumetinib
Docetaxel
AZD5363
Osimertinib
Durvalumab
Sitravatinib
AZD6738
18 Years - University of Birmingham
High-dose Furmonertinib Versus Osimertinib in Advanced EGFRm NSCLC Patients With Brain MetastasesNCT06319950
Lung Cancer, No...
Furmonertinib
Osimertinib
18 Years - 80 YearsTaizhou Hospital
Observational Study of Patients With Locally Advanced or Metastatic NSCLC (Non-Small Cell Lung Cancer)NCT03053297
Carcinoma, Non-...
Patient Reporte...
18 Years - AstraZeneca
National Lung Matrix Trial: Multi-drug Phase II Trial in Non-Small Cell Lung CancerNCT02664935
Non-Small Cell ...
Carcinoma, Squa...
Adenocarcinoma
AZD4547
Vistusertib
Palbociclib
Crizotinib
Selumetinib
Docetaxel
AZD5363
Osimertinib
Durvalumab
Sitravatinib
AZD6738
18 Years - University of Birmingham
Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib TreatmentNCT05261399
Carcinoma
Non-Small-Cell ...
Savolitinib
Osimertinib
Pemetrexed
Cisplatin
Carboplatin
18 Years - 130 YearsAstraZeneca
Osimertinib and Navitoclax in Treating Patients With EGFR-Positive Previously Treated Advanced or Metastatic Non-small Cell Lung CancerNCT02520778
Advanced Lung N...
Metastatic Lung...
Stage III Lung ...
Stage IIIA Lung...
Stage IIIB Lung...
Stage IV Lung N...
Navitoclax
Osimertinib
18 Years - National Cancer Institute (NCI)
Additional Chemotherapy for EGFRm Patients With the Continued Presence of Plasma ctDNA EGFRm at Week 3 After Start of Osimertinib 1st-line Treatment (PACE-LUNG)NCT05281406
NSCLC Stage III...
NSCLC Stage IV
Osimertinib
Pemetrexed
Cisplatin
Carboplatin
18 Years - Goethe University
Osimertinib for Advanced EGFR-positive NSCLC PatientsNCT05037331
EGFR Positive N...
Non Small Cell ...
21 Years - 99 YearsNational University Hospital, Singapore
First Line Osimertinib for EGFR Mutation-positive Non-Small Cell Lung Cancer in Real World Chinese SettingNCT04391283
Carcinoma, Non-...
Osimertinib
18 Years - First Affiliated Hospital of Zhejiang University
Study of Intravenous Telisotuzumab Vedotin in Combination Osimertinib or Standard of Care Chemotherapy to Assess Change in Disease Activity in Adult Participants With Non-Small Cell Lung Cancer That Has a Mutation in the Epidermal Growth Factor Receptor Gene and That Overexpresses the c-Met ProteinNCT06093503
Non-Small Cell ...
Telisotuzumab V...
Osimertinib
Cisplatin
Carboplatin
Pemetrexed
18 Years - AbbVie
Roll Over StudY for Patients Who Have Completed a Previous Oncology Study With Osimertinib (TAGRISSO) (ROSY-T)NCT05629234
Cancer
Osimertinib
18 Years - 99 YearsAstraZeneca
Pharmacokinetic Boosting of OsimertinibNCT03858491
Non Small Cell ...
Cobicistat
18 Years - Academisch Ziekenhuis Maastricht
HER3-DXd (Patritumab Deruxtecan; U3-1402) in Combination With Osimertinib in Subjects With Locally Advanced or Metastatic EGFR-mutated Non-Small Cell Lung CancerNCT04676477
Non-Small Cell ...
HER3-DXd
HER3-DXd
Osimertinib
Osimertinib
HER3-DXd
HER3-DXd
Osimertinib
18 Years - Daiichi Sankyo
Osimertinib Plus Savolitinib in EGFRm+/MET+ NSCLC Following Prior OsimertinibNCT03778229
Carcinoma
osimertinib
savolitinib
placebo
18 Years - AstraZeneca
BBP-398 in Combination With Osimertinib in Locally Advanced or Metastatic NSCLC Patients With EGFR MutationsNCT06032936
NSCLC
BBP-398
osimertinib
18 Years - 99 YearsLianBio LLC
Osimertinib and Etoposide as First-Line Treatment in Osimertinib-Resistant Advanced EGFR-Mutant NSCLCNCT06436144
Non Small Cell ...
EGFR Gene Mutat...
Non Small Cell ...
Non-small Cell ...
Osimertinib
18 Years - 80 YearsDaping Hospital and the Research Institute of Surgery of the Third Military Medical University
PhIb Study Evaluating Safety and Efficacy of Combination Osimertinib and Ipilimumab in Patients w EGFR Mutated NSCLCNCT04141644
Non-Small Cell ...
Ipilimumab
Osimertinib
18 Years - University of Utah
Study of Intravenous (IV) ABBV-637 Alone or in Combination With IV Docetaxel/Osimertinib to Assess Adverse Events and Change in Disease Activity in Adult Participants With Relapsed/Refractory (R/R) Solid TumorsNCT04721015
Advanced Solid ...
Non Small Cell ...
ABBV-637
Docetaxel
Osimertinib
18 Years - AbbVie
A Global Study to Assess the Effects of Osimertinib in Participants With EGFRm Stage IA2-IA3 NSCLC Following Complete Tumour ResectionNCT05120349
Non-Small Cell ...
Osimertinib
Placebo
18 Years - AstraZeneca
TY-9591 in the Patients With EGFR Mutations in Advanced NSCLC With Brain MetastasesNCT05948813
NSCLC
EGFR Activating...
Brain Metastase...
TY-9591
Osimertinib
18 Years - 80 YearsTYK Medicines, Inc
Osimertinib in Treating Patients With Stage IIIB-IV or Recurrent Non-small Cell Lung Cancer With EGFR Exon 20 Insertion MutationsNCT03191149
Advanced Lung N...
Recurrent Lung ...
Stage IIIB Lung...
Stage IV Lung N...
Biospecimen Col...
Computed Tomogr...
Magnetic Resona...
Osimertinib
18 Years - National Cancer Institute (NCI)
Niraparib in Combination With Osimertinib in EGFR-Mutated Advanced Lung CancerNCT03891615
Lung Cancer
Niraparib
Osimertinib
18 Years - Massachusetts General Hospital
Necitumumab and Trastuzumab in Combination With Osimertinib for the Treatment of Refractory Epidermal Growth Factor Receptor (EGFR)-Mutated Stage IV Non-small Cell Lung CancerNCT04285671
Metastatic Lung...
Refractory Lung...
Stage IV Lung C...
Stage IVA Lung ...
Stage IVB Lung ...
Necitumumab
Osimertinib
Quality-of-Life...
Questionnaire A...
Trastuzumab
18 Years - Jonsson Comprehensive Cancer Center
Osimertinib as First-line Therapy for Patients With Late-stage Lung CancerNCT03460275
Non-small Cell ...
Osimertinib Mes...
18 Years - 75 YearsSun Yat-sen University
Osimertinib in Combination With Alisertib or Sapanisertib for the Treatment of Osimertinib-Resistant EGFR Mutant Stage IIIB or IV Non-Small Cell Lung CancerNCT04479306
Recurrent Lung ...
Stage IIIB Lung...
Stage IV Lung C...
Stage IVA Lung ...
Stage IVB Lung ...
Alisertib
Osimertinib
Sapanisertib
18 Years - M.D. Anderson Cancer Center
Phase III Study of TY-9591 in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (FLETEO)NCT05382728
NSCLC
EGFR Activating...
TY-9591
placebo Osimert...
Osimertinib
placebo TY-9591
18 Years - 80 YearsTYK Medicines, Inc
A Molecular Profiling Study of Patients With EGFR Mutation-positive Locally Advanced or Metastatic NSCLC Treated With OsimertinibNCT03239340
EGFR Mutation P...
Osimertinib
18 Years - 130 YearsAstraZeneca
Prospective Cohort of Locally Advanced and Metastatic Non-Small Cell Lung Cancer Patients With Activating EGFR MutationsNCT05103605
Non Small Cell ...
Osimertinib
18 Years - AstraZeneca
Osimertinib Plus Bevacizumab in Untreated EGFR Exon21 L858R Mutated NSCLCNCT04988607
Lung Cancer
Osimertinib
Bevacizumab
Osimertinib
18 Years - Guangdong Association of Clinical Trials
First-line Treatment With Osimertinib in EGFR-mutated Non-small Cell Lung CancerNCT03804580
Lung Cancer
osimertinib
18 Years - Vestre Viken Hospital Trust
Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain MetastasesNCT02971501
Metastatic Lung...
Metastatic Mali...
Stage IV Lung C...
Bevacizumab
Biopsy
Biospecimen Col...
Computed Tomogr...
Magnetic Resona...
Osimertinib
18 Years - National Cancer Institute (NCI)
A Study of the Combination of Osimertinib, Platinum and Etoposide for Patients With Metastatic EGFR Mutant Lung CancersNCT03567642
Lung Cancer
Osimertinib
Platinum
Etoposide
18 Years - Memorial Sloan Kettering Cancer Center
Osimertinib and Bevacizumab as Treatment for EGFR-mutant Lung CancersNCT02803203
Non-small Cell ...
EGFR-mutant Lun...
osimertinib
Bevacizumab
19 Years - Memorial Sloan Kettering Cancer Center
Bevacizumab Plus EGFR-TKIs in Chinese Patients With EGFR-mutant NSCLC: a Real-world StudyNCT04575415
NSCLC
Bevacizumab
Erlotinib
Gefitinib
Icotinib
Afatinib
Dacomitinib
Osimertinib
18 Years - 75 YearsGuangdong Association of Clinical Trials
Durvalumab vs Placebo With Stereotactic Body Radiation Therapy in Early Stage Unresected Non-small Cell Lung Cancer (NSCLC) Patients / Osimertinib Following SBRT in Patients With Early Stage Unresected NSCLC Harboring an EGFR MutationNCT03833154
Carcinoma, Non-...
Durvalumab
Placebo
Osimertinib (si...
18 Years - 130 YearsAstraZeneca
Osimertinib With or Without Savolitinib as 1L in de Novo MET+, EGFR+ NSCLCNCT05163249
Carcinoma, Non-...
Osimertinib
Savolitinib
18 Years - Guangdong Association of Clinical Trials
A Randomised Phase II Trial of Osimertinib With or Without SRS for EGFR Mutated NSCLC With Brain MetastasesNCT03497767
Metastatic Non ...
Osimertinib
Stereotactic Ra...
18 Years - Trans Tasman Radiation Oncology Group
Real-world Analysis of Workup at Disease Progression and Implementation of Osimertinib for EGFR+ NSCLCNCT04105153
EGFR Positive N...
18 Years - Thoraxklinik-Heidelberg gGmbH
Osimertinib in Treating Participants With Stage I-IIIA EGFR-mutant Non-small Cell Lung Cancer Before SurgeryNCT03433469
Stage I Non-Sma...
Stage IA Non-Sm...
Stage IB Non-Sm...
Stage II Non-Sm...
Stage IIA Non-S...
Stage IIB Non-S...
Stage IIIA Non-...
Osimertinib
Therapeutic Con...
18 Years - University of California, San Francisco
(SYMPHONY) Phase 1/2 Study Targeting EGFR Resistance Mechanisms in NSCLCNCT04862780
Lung Neoplasms
Carcinoma, Non-...
Respiratory Tra...
Neoplasms
Neoplasms by Si...
Lung Diseases
Respiratory Tra...
Carcinoma, Bron...
Bronchial Neopl...
Adenocarcinoma
Carcinoma
Neoplasms by Hi...
Neoplasms, Nerv...
EGFR T790M
EGFR C797S
EGFR L858R
EGFR Gene Mutat...
EGF-R Positive ...
EGFR Exon 19 De...
EGFR Mutation R...
EGFR Activating...
Protein Kinase ...
Antineoplastic ...
Thoracic Neopla...
BLU-945
osimertinib
18 Years - Blueprint Medicines Corporation
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