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Brief Title: Phase I Study of OSI-930 and Erlotinib in Cancer Tumors
Official Title: A Phase 1 Dose Escalation Study of Daily Oral OSI-930 and Erlotinib (Tarceva) in Patients With Advanced Solid Tumors
Study ID: NCT00603356
Brief Summary: This is a Phase I, dose escalation, safety study of OSI-930 and Erlotinib in cancer tumors.
Detailed Description: Multicenter, open-label, phase 1, dose escalation study to determine the maximum tolerated dose of OSI-930 and Erlotinib. Patients may continue to receive OSI-930 and Erlotinib until one of the following occurs: disease progression, adverse event requiring withdrawal, failure to recover from toxicity despite a 14-day dosing interruption, medical or ethical reasons, patient request, or patient death.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States
The Beatson West of Scotland Cancer Centre, Glasgow, , United Kingdom