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Brief Title: Multiscale Omics for the Development of a Cohort Database and Study Platform in Breast Cancer Survivors
Official Title: Use of Multiscale Omics to Develop a Cohort Database and Study Platform in Breast Cancer Survivors
Study ID: NCT04999826
Brief Summary: This study gathers information to create a database to improve the ability to diagnose cancer, predict long term health of breast cancer patients, and help develop future treatment products. This study will provide a foundational platform for therapeutic development and intervention studies in the future and may for therapeutic development and intervention studies in the future, and may advance researchers understanding of the contribution gut bacteria to altered circulating estrogens in breast cancer survivors.
Detailed Description: PRIMARY OBJECTIVE: I. To use multiscale omics to build a cohort database that can be used as a reference population in support of multivariate analysis, predictive modeling, and development of natural product therapeutics and precision medicine applications for breast cancer survivors. SECONDARY OBJECTIVE: I. To detect unique patterns of variance between 1) targeted serum metabolites, 2) plasma metabolome, 3) gut microbiome community structure, 4) gut microbiome metabolome, 5) urine metabolome, 6) quality of life measures, and 7) breast cancer survivors (BCS) symptoms by using multivariate analysis, machine learning tools, and artificial intelligence applied to the large data sets developed in this trial. OUTLINE: Participants complete questionnaires over 10 minutes and undergo blood, urine, saliva, and fecal samples collection.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: Yes
Mayo Clinic in Rochester, Rochester, Minnesota, United States
Name: Brent A Bauer
Affiliation: Mayo Clinic in Rochester
Role: PRINCIPAL_INVESTIGATOR