Spots Global Cancer Trial Database for Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients

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Trial Identification

Brief Title: Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients

Official Title: Cardiovascular Research Consortium - a Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients

Study ID: NCT03444259

Conditions

Atrial Fibrillation

Coronary Artery Disease

Aortic Valve Stenosis

Interventions

Cardiac surgery

Study Description

Brief Summary: The objective of CAREBANK study is to establish definitive relationships with human cardiac samples and clinical phenotypes in patients undergoing cardiac procedures. Specifically, the investigators aim at comparing atrial phenotypes from atrial fibrillation patients and controls. The work consists of three broad categories: A) role of atrial cardiomyopathy in atrial fibrillation; B) genetic defects predisposing to atrial fibrillation; and C) the role of inflammation in atrial fibrillation.

Detailed Description: The investigators aim to A) compare atrial cardiomyopathy findings from the tissue samples to clinical phenotype and adverse events B) study the association of genetic defects predisposing to atrial fibrillation with atrial cardiomyopathy findings in the tissue samples C) assess the role of inflammation in atrial fibrillation by comparing circulating cytokine profiles, purinergic signaling and atrial cardiomyopathy findings in tissue samples.